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  • Novel Psychoactive Substances of Abuse: Part I

    This issue is the first of a two-part series on new novel or designer psychoactive drugs. Many of them represent alterations of existing agents that exhibit new effects from the modification. Keep the possibility of intoxication with these agents in mind when evaluating patients with altered levels of consciousness and mentation.

  • The Silent Epidemic: Hepatitis C Virus

    Hepatitis C accounts for a significant burden of disease. There are many barriers to the eradication of hepatitis C virus (HCV), from infection identification to treatment, making it a very complex public health concern. Unfortunately, no vaccine for HCV exists yet, and development proves difficult because of the overwhelming genetic diversity. HCV can be treated by a patient’s primary care physician; this group is instrumental in screening for and treating hepatitis C.

  • Glymphatic and Lymphatic Functions in Patients with Chronic Migraine

    Patients with chronic migraine have dysfunction of their glymphatic and meningeal lymphatic systems, which may play a role in the pathogenesis of migraine.

  • Comparing Patients with Early vs. Late-Onset Multiple Sclerosis

    A recent retrospective study, combining data from a United Kingdom patient registry with a United Kingdom neuropathology tissue bank, showed that late-onset multiple sclerosis (MS), referring to disease onset after age 50 years, is linked with increased disability and quicker progression compared to MS onset at a younger age, and has distinct pathological features.

  • MRI for the Evaluation of Inflammatory Myopathy

    Magnetic resonance imaging (MRI) of large muscles is an important adjunctive diagnostic test for inflammatory myopathies, in conjunction with serum muscle enzymes and electrophysiology. MRI also can identify the highest-yielding section of muscle to target a muscle biopsy.

  • Timing of Biomarker Changes in Alzheimer’s Disease

    In a longitudinal multicenter, nested case-control study of cognitive normal participants from China, the time courses of key Alzheimer’s disease biomarkers were identified during the 20 years preceding clinical diagnosis of sporadic Alzheimer’s disease.

  • Post-Traumatic Epilepsy and the Risk of Dementia

    A subset of people with head injury will develop post-traumatic epilepsy (PTE). This prospective cohort study demonstrated a 4.5-fold increased risk of dementia in those with PTE compared to people without head trauma or epilepsy, and that this risk exceeds that observed in people with head trauma or epilepsy alone.

  • Infectious Disease Alert Updates

    The Gut Biome and Social Determinants of Health: A Factor in C. diff Infection?

    Pre-Op Screening for SARS-CoV-2 Is Not Cost Effective

  • Acanthamoeba Infection and Nasal Rinsing

    This study from the Centers for Disease Control and Prevention reviewed 10 cases of patients with a history of nasal rinsing who developed Acanthamoeba infection.

  • Infections, Including Endocarditis, Due to Non-Toxigenic Corynebacterium diphtheriae

    Evidence indicates increasingly frequent recovery of non-toxigenic Corynebacterium diphtheriae in wound cultures, along with further recognition of endocarditis caused by this organism.