The opening of ATP-sensitive potassium channels by levcromakalim triggered migraine headaches in all migraineurs. In healthy volunteers, levcromakalim induced milder headaches associated with long-lasting dilation of extracerebral arteries.
Vertigo is a common and integral component of migraine and occurs with neuro-otologic abnormalities and psychiatric comorbidities. Treatment of episodic vertigo suspected to be due to vestibular migraine should mirror the multimodality treatment of migraine.
The degree of unexpectedness or “surprisal” associated with known migraine triggers is a predictor of headache attacks. Social avoidance behavior is positively correlated with headache disability, pain, and depression, but there is a negative correlation between headache pain endurance and anxiety.
In this observational, cross-sectional survey performed via an online questionnaire, researchers confirmed that alcohol consumption is a common trigger for migraine, and red wine is the type of alcohol cited as a trigger most frequently.
Migraines occur in young children, but may be challenging to diagnose. Migraines can have a great impact on pediatric patients’ quality of life with school absence and limitations on extracurricular activities. Treatment of pediatric migraines or possible migraines is difficult secondary to the lack of evidence for effective therapies in pediatric patients. Treatment includes traditional therapy with dopamine receptor antagonists (DRAs), nonsteroidal anti-inflammatory drugs (NSAIDs), triptans, and combination therapies. Newer therapies include magnesium, valproic acid (VPA), and peripheral nerve blocks. The authors review the clinical presentation of migraines in children, guidelines for diagnosis, and therapeutic options.