Investigators of this well-designed, randomized, controlled trial conclusively demonstrated that progesterone supplementation does not reduce the risk of early pregnancy loss in women who experience first trimester bleeding.
In this randomized, controlled trial of more than 3,000 women in developing countries with incomplete or missed abortion at less than 22 weeks’ gestation, antibiotic prophylaxis prior to uterine evacuation reduced infection rates when a strict definition for pelvic infection was used, but not when a more expanded definition was used.
Results from a collaborative study indicate 26% of nonhuman primates that became infected with the Zika virus early in pregnancy experienced miscarriages or stillbirths, although the animals exhibited few signs of the infection.
Early pregnancy failure typically is defined as an intrauterine pregnancy in the first trimester that is not viable, either because the gestational sac is empty or because the embryo or fetus has no cardiac activity. This article will discus the main options for the management of early pregnancy failure: expectant management, medical management with misoprostol, and surgical management. Women’s preferences should guide treatment decisions, given that all three options are medically safe.
In a meta-analysis, a history of dilation and curettage for management of miscarriage or termination of pregnancy was associated with an increased risk of preterm birth in a subsequent pregnancy but the association is weak and most likely explained by confounding.