Articles Tagged With: myopathy
-
Myopathy with Elevated Aldolase and Normal CK: Differential Diagnosis
Elevated serum creatine kinase (CK) is considered the hallmark of myopathy, yet some patients with biopsy-proven myopathy have normal CK with elevated aldolase, a less-specific marker of muscle disease. Most of those cases ultimately prove to be dermatomyositis.
-
Inclusion Body Myositis: Variability and Clinical Subsets
Inclusion body myositis (IBM) is a progressive myopathy characterized by prominent finger flexor and quadriceps involvement. Black patients with IBM have more prominent proximal weakness, in addition to finger flexion and quadriceps weakness. Female patients have less prominent finger flexion and quadriceps weakness and slower progression, whereas younger patients had a greater delay in diagnosis. There are variability and distinct clinical subsets among IBM patients, which can have implications in terms of timely diagnosis and possibly response to treatments.
-
What Is Oculopharyngodistal Myopathy?
Distal limb myopathies are rare disorders and are difficult to diagnose. Current muscle biopsy technology, coupled with genetic analysis, offers the best hope for an accurate diagnosis of these unusual neuromuscular disorders. Unfortunately, treatments remain elusive.
-
Atypical Presentations for Inclusion Body Myositis
Inclusion body myositis, the most common acquired myopathy, often is misdiagnosed or diagnosed after a delay of many years. Atypical presentations are not unusual, and clinicians should maintain a high degree of suspicion for this disorder when patients present with slowly progressive muscle weakness in an unusual pattern.
-
Myopathy Is Associated with Post-COVID-19 Fatigue
Prolonged fatigue after COVID-19 infection may be associated with evidence of myopathy, based on physical examination, electromyography, and muscle biopsy.
-
Gene and Substrate Therapy for Neurogenetic Disease: A Combined Approach to Treat Mitochondrial Myopathy
A combined adenoviral-mediated gene therapy plus substrate therapy delivered to a mouse model of thymidine kinase 2 (TK2) deficiency, manifested most often as a fatal mitochondrial myopathy in infants and children, rescued TK2 activity and prolonged animal lifespan, thus indicating a promising therapeutic approach for affected patients.
-
Statins and Muscle Symptoms: Cause and Effect?
An analysis of three large simvastatin trials revealed muscle symptoms on simvastatin are common, but true myopathy is rare and can be predicted by evaluating certain risk factors for its development, which can help guide patient management.
-
Correlation of Electromyography With Pathology in Myopathy
A detailed analysis of electromyography features showed a high correlation with muscle pathology. However, pathologic changes on muscle biopsy may be present even with a totally normal electromyogram.
-
Isolated Amyloid Myopathy
Isolated amyloid myopathy is a rare disorder that can be distinguished from systemic amyloidosis with myopathy by clinical, biochemical, and muscle biopsy histologic criteria.