In this case control study using U.S. live birth records between 22 and 23 weeks of gestation, maternal intervention was positively associated with increasing maternal age, Medicaid use, preeclampsia, birth defects, twin gestation, multiparity, and infertility treatments while being negatively associated with non-Hispanic Black race. Positive associations for neonatal intervention included non-Hispanic Black race, preeclampsia, Medicaid use, infertility treatments, less than a high school education, increasing maternal age, and twin gestation, and negative associations included birth defects and small for gestational age pregnancies.
In this large, double-blind, placebo-controlled, international trial, pregnant women at risk for preterm birth (PTB) between 16-36 weeks gestational age were randomized to an intramuscular weekly injection of either 17-hydroxyprogesterone caproate (17P) or placebo. There was no difference in rates of PTB or neonatal morbidity between these two groups. In comparison to the Meis trial published in 2003, the findings of the PROLONG trial question the use of intramuscular 17P injection as the cornerstone of PTB prevention.
Neonatal herpes infection usually presents with seizure, vesicular rash, or critical illness. The subset of infected patients without those signs were younger than two weeks of age and/or had cerebrospinal fluid pleocytosis.
Although a recent study has failed to show major benefit from delayed umbilical cord clamping, others have suggested neonates having delayed cord clamping have less need for transfusion, higher hematocrits, less neonatal morbidity, and diminished risk of intraventricular hemorrhage.