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Articles Tagged With: neurologic

  • Mpox-Associated Neurological Disease

    Neurological consequences of mpox (monkeypox) are rare and have not been attributed to direct viral invasion of the central nervous system.

  • Genetic Evaluation of Hereditary Spastic Paraplegia

    Hereditary spastic paraplegia (HSP) refers to a group of rare, clinically heterogenous degenerative neurogenetic disorders resulting in spasticity, gait impairment, and falls as the result of a length-dependent upper motor neuron degeneration. Next-generation sequencing with multigene panels or exome analysis can confirm molecular diagnosis of approximately 30% of HSP patients. Multigene panels can identify the common causative variants, variants on rarely involved genes, and structural rearrangements.

  • Genetic Evaluation of Hereditary Spastic Paraplegia

    Hereditary spastic paraplegia (HSP) refers to a group of rare, clinically heterogenous degenerative neurogenetic disorders resulting in spasticity, gait impairment, and falls as the result of a length-dependent upper motor neuron degeneration. Next-generation sequencing with multigene panels or exome analysis can confirm molecular diagnosis of approximately 30% of HSP patients. Multigene panels can identify the common causative variants, variants on rarely involved genes, and structural rearrangements.

  • Organ Donation: Perspective for the Intensivist

    Organ donation and transplantation are important and lifesaving procedures.The complexities of management include determination of death, communication with families, pre-procurement optimization of potential donors, and bereavement support for families.

  • Adenovirus and CNS Disease in Children

    Forty-eight immunocompetent children with adenovirus-associated central nervous system disease were described. Thirty-eight percent of patients died or experienced permanent neurologic sequelae.

  • Subarachnoid Hemorrhage and Intracranial Hemorrhage

    Time is of the essence in management of intracranial hemorrhage and subarachnoid hemorrhage. The longer it takes to make the diagnosis and initiate treatment, whether it is surgical intervention or simply aggressive primary stabilization, the greater the risk to the patient regarding both morbidity and mortality.

  • Spinal Cord Injury

    The spinal cord, although well protected, can be injured in a variety of ways, including motor vehicle collisions and sporting events. The inability of the neurons to regenerate, and their sensitivity to anoxia and hypoperfusion, makes the timely diagnosis and treatment of spinal cord injury imperative to preserve as much function as possible. This article will cover the basic epidemiology, physiology, and treatments for spinal cord injury in an attempt to prepare the reader to manage these complex injuries.