Articles Tagged With: neuromuscular
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Electrophysiology, Muscle Ultrasound, and MRI in the Diagnosis of Neuromuscular Disorders
To accomplish accurate diagnosis of nerve and muscle disorders, clinical collaboration with ultrasound and magnetic resonance imaging experts is invaluable and can provide critically important information beyond electrophysiology.
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Zilucoplan Injection (Zilbrysq)
The U.S. Food and Drug Administration has approved a once-daily subcutaneously administered drug for the treatment of generalized myasthenia gravis in adult patients who are anti-acetylcholine receptor antibody positive. Zilucoplan is macrocyclic peptide that inhibits the cleavage of complement 5 (C5) to C5a and C5b.
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Nitrous Oxide-Induced Neuropathy
Nitrous oxide-induced neuropathy presents with a rapidly progressive sensorimotor neuropathy that may mimic Guillain-Barré syndrome. The pattern of clinical weakness and progression, as well as electrophysiological features, can help to rapidly distinguish the two disorders.
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What Is Oculopharyngodistal Myopathy?
Distal limb myopathies are rare disorders and are difficult to diagnose. Current muscle biopsy technology, coupled with genetic analysis, offers the best hope for an accurate diagnosis of these unusual neuromuscular disorders. Unfortunately, treatments remain elusive.
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COVID-19 Vaccination in Patients with Autoimmune Neuromuscular Diseases
In a population-based, self-reporting survey of patients with immune-mediated myopathy and myasthenia gravis, the frequency of both mild and severe acute adverse events appeared to be no more frequent than in the general population. COVID-19 vaccinations are safe for this population of patients.
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Neuromuscular Complications of Graft-Versus-Host Disease
Graft-versus-host disease is common in allogeneic bone marrow recipients, but neuromuscular complications are unusual (8%). The most common neuromuscular complication is an immune-mediated myositis that responds to treatment with immunosuppressive therapies.
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Rhabdomyolysis Etiology
Rhabdomyolysis can be a life-threatening condition that often triggers a neurology consultation during an investigation for cause. However, in this recent study, the majority of cases (79%) were triggered by external, non-neuromuscular causes, and the others, although suspicious for an intrinsic muscular or genetic cause, rarely had a specific diagnosis confirmed.
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Early Neuromuscular Blockade in Moderate-to-Severe Acute Respiratory Distress Syndrome
When the early use of a continuous infusion of cisatracurium was compared to contemporary supportive care for moderate-to-severe ARDS, including a light sedation target, high positive-end expiratory pressure, and conservative fluid strategy, there was no difference in 90-day mortality. Patients in the early neuromuscular blockade group more frequently experienced a severe cardiovascular event and ICU-acquired weakness by day 28.