Articles Tagged With: progesterone
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The Studied and Unstudied Dangers of ‘Abortion Reversal’
Colorado’s Senate Bill 190, signed in May 2023, declared the practice of “abortion reversal” to be unprofessional conduct, meaning that healthcare providers providing this treatment could face sanctions to their licensure. However, Colorado’s Medical Board subsequently issued a draft rule declaring “abortion reversal” as “generally accepted standard of practice” and, therefore, potentially acceptable. Clearly, confusion exists among state medical boards and legislatures, and, potentially, among healthcare providers. This commentary will review both the medical evidence regarding “abortion reversal” and the legal context so that providers can be better informed and communicate the best evidence to their patients.
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Hormonal Contraceptives Help Women Manage Perimenopause
Women near the end of their reproductive years may experience fewer perimenopausal symptoms if they use a hormonal contraceptive, such as a hormonal intrauterine device.
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IUD Perforations Are Rare, but Risk Is Slightly Higher for Nursing Mothers
New research shows that perforation from IUDs is incredibly rare, although the risk is slightly higher with breastfeeding at the time of insertion. Overall, the rate of any perforation was fewer than two per 1,000 person-years.
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Oral Progestogens for Prevention of Miscarriage
In this double-blind, randomized clinical trial, 406 pregnant women were randomized to dydrogesterone or placebo. There were no statistically significant differences in the primary outcome (miscarriage before 20 weeks of gestation; relative risk, 0.897; 95% confidence interval, 0.548-1.467; P = 0.772), which occurred in 12.8% and 14.3% in the dydrogesterone and placebo arms, respectively. The use of dydrogesterone in women with threatened miscarriage for the prevention of early pregnancy loss in the first trimester failed to decrease the miscarriage rate or increase the live birth rate.
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Progesterone: Not a Treatment for Threatened Abortion
Investigators of this well-designed, randomized, controlled trial conclusively demonstrated that progesterone supplementation does not reduce the risk of early pregnancy loss in women who experience first trimester bleeding.
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Vaginal Progesterone vs. Cerclage to Prevent Preterm Birth
SYNOPSIS: A recent indirect comparison meta-analysis has shown that vaginal progesterone is as useful in decreasing preterm birth and its associated adverse outcomes as cervical cerclage in patients with a history of preterm birth and short cervices.
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17 P vs. Vaginal Progesterone
A recent randomized study suggested that vaginal progesterone is at least as good as, and may be superior to, intramuscular 17 alpha-hydroxy progesterone caproate in preventing recurrent preterm birth, but shortcomings in the study indicate that more investigation is needed.
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Endometrial Protection: Which Progestogen Is Best?
After a lost decade, increasing numbers of women and providers are recognizing the benefits of postmenopausal hormonal therapy. For women with an intact uterus, endometrial protection is required when systemic estrogen therapy is used. Since activity at the glucocorticoid and androgen receptor may lead to adverse health effects in some women, use of pure progesterone receptor agonists may offer advantages. However, the use of natural progesterone is problematic due to low potency and poor bioavailability with oral dosing. Local therapy with the levonorgestrel intrauterine device (off-label) may be an excellent choice for many women.