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Articles Tagged With: progression

  • Comparing Patients with Early vs. Late-Onset Multiple Sclerosis

    A recent retrospective study, combining data from a United Kingdom patient registry with a United Kingdom neuropathology tissue bank, showed that late-onset multiple sclerosis (MS), referring to disease onset after age 50 years, is linked with increased disability and quicker progression compared to MS onset at a younger age, and has distinct pathological features.

  • Treatment of Preclinical Alzheimer’s Disease

    After a four-year, complex clinical trial of an anti-amyloid antibody, solanezumab, there was no benefit in reducing the likelihood of progression of cognitive impairment in patients with positive amyloid positron emission tomography scans who started the trial cognitively unimpaired vs. placebo.

  • Glycoprotein IIb/IIIa Receptor Inhibitor Tirofiban for Ischemic Stroke

    Glycoprotein IIb/IIIa receptor inhibitors are potent, rapidly acting antiplatelet agents that have been tried in pilot studies to treat acute ischemic stroke, without significant benefit. Tirofiban is fast-acting, highly selective, and has a short half-life that allows bleeding time to return to normal within three hours after administration is stopped. The investigators proposed that this medication may be of benefit in patients with acute ischemic stroke who arrived within 24 hours after stroke onset but are not eligible for thrombolysis or thrombectomy or have progression of stroke symptoms after receiving thrombolysis.

  • CIN2 Is More Likely to Progress if HPV 16 Is Present

    This study examined rates of cervical intraepithelial neoplasia grade 2 (CIN2) regression and progression among women ages 25-30 years and found that regression rates varied by human papillomavirus (HPV) genotype: 51% regression and 47% progression in HPV 16 infections compared to 83% regression and 16% progression for infections with other HPV types.

  • White Matter Hyperintensities and Progression of Parkinsonism in Older Adults

    Both higher levels of cerebral white matter hyperintensities and cerebrovascular disease pathologies may be associated with a more rapid progression of parkinsonism in older adults.

  • Is Physical Activity Associated with Mortality Risk in Parkinson’s Disease?

    In individuals with Parkinson’s disease (PD), physical activity (PA) at all intensities was associated with lower all-cause mortality rates, with the greatest reduction seen in individuals who maintained PA before and after PD diagnosis.

  • Predicting the Progression of Chronic Aortic Regurgitation

    A large database observational study of patients with chronic aortic mild or moderate regurgitation (AR) largely due to bicuspid aortic valve or aortic root dilatation showed that it was largely an indolent disease, with only 20% progressing to moderately severe AR in five years.

  • Unexpected Benefit of Pneumococcal Vaccine in Decreasing the Burden of Otitis Media

    Surveillance data collected prospectively in Israel reveal a decline in progression from pneumococcal carriage to complex otitis media in both vaccine-targeted and non-vaccine serotypes following implementation of routine use of pneumococcal conjugate vaccines. Vaccinating against pneumococcal serotypes causing early-life infections may reduce the risk of subsequently developing complex otitis media due to other organisms.

  • Treatment of Pulmonary Mycobacterium avium Infection: Failure Is Common

    Current treatment regimens for pulmonary Mycobacterium avium infection leave a great deal to be desired.