Study: Interferon Does Not Help Hospitalized COVID-19 Patients

When combined with remdesivir, the multiple sclerosis drug did not produce clinical benefit.

Q&A: Data Safety Monitoring Board Experts Explain Role in Clinical Research

Data safety monitoring boards (DSMBs) have played a big role in delivering vaccines and treatments to the public faster in the past 18 months. DSMBs reviewed results and safety data of the various studies involving treatments and vaccines for COVID-19. IRB Advisor asked two scientists about how DSMB work has helped improve research protections during the pandemic.

The Effect of Antiviral Drugs on COVID-19 Outcomes and Mortality

The WHO Solidarity Trial Consortium found that remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had “little or no effect” on relevant outcomes.

Treatment of COVID-19 Patients with Remdesivir, Hydroxychloroquine, Lopinavir, or Interferon Beta-1a

None of the four drugs studied was superior to placebo.

A Review of Current Therapeutics for Severe COVID-19 Pneumonia

The aim of this special feature is to review therapeutic options for hospitalized patients with COVID-19 pneumonia.

Remdesivir Injection (Veklury)

Remdesivir’s benefit appears to be modest, but may be better for those receiving low-flow oxygen.

Early Data on Remdesivir for Severe COVID-19: A Promising Start?

In this group of patients hospitalized with severe COVID-19, most of whom required invasive ventilation, 68% showed clinical improvement after treatment with remdesivir on a compassionate-use basis.

Biometrics Expert Discusses Data Integrity for COVID-19 Clinical Trials

The first remdesivir double-blind, placebo-controlled clinical trial for treating COVID-19 was published recently in Lancet. A member of the trial’s data safety monitoring board is Weichung Shih, PhD. Shih discussed the role of biostatisticians in protecting data integrity for clinical trials and the challenges during the COVID-19 pandemic.

Remdesivir and COVID-19

Remdesivir is safe and moderately effective in the treatment of patients with COVID-19.

Remdesivir Injection

Under a federal emergency authorization, remdesivir can be used to treat suspected or laboratory-confirmed COVID-19 in children or adults who are hospitalized with severe disease.

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