Articles Tagged With: thiamine
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Influence of Vitamin Intake on the Prevalence of Migraine
In a large population-based survey, 21.6% of participants reported having severe headaches or migraine. Those reporting severe headaches also reported a lower intake of thiamine and riboflavin, based on 24-hour recall of food intake. There also was an inverse relationship between thiamine intake and reports of severe headaches.
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Complications from Gastric Bypass Surgery Result in Brain Injury, $14.1 Million Award
A patient underwent gastric bypass surgery, but suffered permanent brain damage because of post-surgery complications and requires around-the-clock care for the rest of her life. The patient sued, alleging that the physician who performed the procedure failed to recognize that she was suffering from a severe thiamine and vitamin B1 deficiency, which led to her injuries. A jury awarded a $14.1 million verdict. The defendant physicians appealed, but the appellate court affirmed the verdict.
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Vitamin C, Thiamine, and Steroids for Septic Shock — Still Unproven
Combination treatment with ascorbic acid (vitamin C), thiamine (vitamin B1), and corticosteroids does not improve clinical outcomes in adults with septic shock.
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Considerations and Concerns with Vitamin C in Sepsis and Septic Shock
Sepsis remains a major healthcare problem associated with significant morbidity and mortality. Roles for hydrocortisone, ascorbic acid (vitamin C), and thiamine (HAT therapy) as potential adjuvants remain controversial.
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ORANGES and ACTS Trials: No Mortality Benefit with Ascorbic Acid, Thiamine, and Hydrocortisone in Septic Shock Patients
Two double-blinded, placebo-controlled, randomized trials involving 337 patients (ORANGES, n = 137; ACTS, n = 200) with sepsis and septic shock have shown that administration of ascorbic acid, thiamine, and hydrocortisone did not reduce organ dysfunction or improve overall mortality. However, both trials showed that this combination therapy was effective in reducing the time to achieve shock resolution or shock-free days.
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Vitamin C, Thiamine, and Hydrocortisone for Septic Shock
The combination of vitamin C, thiamine, and hydrocortisone did not improve outcomes compared with hydrocortisone alone in patients with septic shock.