Depression is a multifaceted recurrent disease of growing prevalence. The World Health Organization reports that depression will be the second leading cause of disability worldwide by 2020.

Newly released research indicates that a certain combination of drugs, gentamicin and azithromycin, may work as well as ceftriaxone alone for cases of drug-resistant gonorrhea.

About 80% of new HIV transmissions can be linked to people whose infection is undiagnosed or is not currently treated, according to findings from a just-published analysis.

Researchers are exploring the use of metronidazole for the treatment of endometriosis, which affects up to 10% of U.S. women between the ages of 25 and 40. The current treatment options include hormone therapy and surgery, but these approaches involve significant side effects and recurrence of the condition after treatment.

Histoplasmosis is increasingly seen beyond the previous risk areas of the Ohio and Mississippi River valleys. Diagnostic and treatment practices vary widely.

In a randomized clinical trial, researchers found the combination of oral vancomycin followed by fecal microbiota transplantation was superior to treatment with fidaxomicin or vancomycin alone for patients with recurrent Clostridioides difficile infection.

According to a new report, serious gaps exist in the research pipeline regarding the development of prevention and treatment options for sexually transmitted infections such as gonorrhea, chlamydia, and syphilis.

New guideline recommendations indicate that the only unequivocal indications for screening and treatment of asymptomatic bacteriuria are pregnancy and undergoing endoscopic urologic procedures associated with mucosal injury.

In a randomized, controlled trial of adult patients with bone or joint infections, researchers found oral antibiotic therapy was noninferior to intravenous therapy based on treatment failure at one year.

All emergency providers should be familiar with hypothermia regardless of the climate in which they practice. Hypothermia can occur in a variety of climates, indoors or outdoors, and in patients of all ages regardless of health status. Frostbite, chilblains, trench foot, and cold urticaria are cold-related injuries that may present to any emergency department during any time of year.