Articles Tagged With: tuberculosis
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Occupational Health: Outbreak Investigation 101
In an outbreak situation that affects healthcare workers and patients, occupational health can strike a critical partnership with the infection control department to rapidly resolve the situation.
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With No Annual HCW Screening, Treatment of Latent TB Imperative
The CDC dropped its labor-intensive recommendation for annual routine screening of healthcare workers for tuberculosis (TB) in 2019. However, there are multiple TB issues with which occupational health departments must contend. These include post-hire pre-placement testing, treating latent TB that could activate later in life, identifying and following up on worker exposures, and the threat of multidrug-resistant strains.
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Infectious Disease Alert Updates
Cardiac Effects of Bedaquiline and Delamanid in Combination; Is Leprosy ‘Endemic’ in Florida?; Linezolid Dosing in Cardiac Surgery
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Shortening the Duration of Tuberculosis Treatment
In patients with rifampin-susceptible tuberculosis, a planned eight-week regimen of bedaquiline plus linezolid together with isoniazid, ethambutol, and pyrazinamide, combined with a careful follow-on strategy, was non-inferior to a standard six-month regimen.
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TB Rates Are Rising Again
In 2020, the TB rate dropped to 2.2, possibly because COVID-19 demanded public health resources that might have been used to detect it, and travel and immigration declined. After a small rebound in 2021, TB levels climbed to 2.5 cases per 1,000 people in 2022. There were more than 8,000 cases, and the CDC said TB was returning to pre-pandemic levels.
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Infectious Disease Alert Updates
California Firefighters at Risk for Cocci; Hyperglycemia and Diabetes with INSTIs; Positive Sputum in Extra-Pulmonary Tuberculosis
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An Effective Oral Regimen for Rifampin-Resistant Tuberculosis
A multicenter, randomized, controlled, noninferiority clinical trial found a 24-week, all-oral regimen (bedaquiline, pretomanid, linezolid, and moxifloxacin) to be safe and effective for patients aged 15 years and older with rifampin-resistant tuberculosis.
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It’s Not All About the Cough
Be careful about relying on clinical queries that focus on the presence of cough for two or more weeks, which could lead to delays in the diagnosis of nearly half of pulmonary tuberculosis cases.
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WHO Lobbies for Updated Tuberculosis Vaccines
International organization says these investments could drive economic growth, improve health equity and antimicrobial stewardship, and lower mortality rates.
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Multi-State Tuberculosis Outbreak Due to Transmission from an Infected Bone Graft Product
An 80-year-old man with undiagnosed tuberculosis (TB) became a bone tissue donor after his death from a cardiac arrest. Bone graft product was given to 113 recipients in 20 states, of whom three died of TB. All living recipients were started on treatment for TB at a median of 69 days after bone product implementation.