In adults >18 years, taking immunosuppressive medications at the time of zoster vaccination increased the risk for herpes zoster for up to 6 weeks afterward (adjusted odds ratio, 2.99; 95% CI, 1.58-5.70).
In a population-based study, neonatal vaccination with bacille Calmette-Guérin significantly reduced rates of hospitalization for non-tuberculous respiratory infection and sepsis. BCG vaccine might provide significant protection through nonspecific immune enhancement.
A large study of HPV vaccination among girls 13-14 years of age demonstrated significant reduction of cervical dysplasia that was detectable by 17 years of age, providing justification for not delaying HPV vaccination in girls until older adolescence.
Physicians can improve the health of unaccompanied Central American immigrant children by ensuring appropriate vaccination, by identifying culturally and linguistically appropriate community resources, and by becoming involved in patient advocacy.
A comprehensive, independent review of 10 years of all cases in the United States of seizures and encephalopathy reported as linked to vaccination showed that approximately one-quarter of cases had evidence of a pre-existing neurologic abnormality. Among those who developed chronic epilepsy, many had clinical features suggesting genetically determined epilepsy, especially Dravet syndrome.