In this randomized clinical trial, 343 pregnant women with twin gestations were randomized to planned cesarean delivery and planned vaginal delivery groups (208 patients vs. 135 patients, respectively) between October 2013 and March 2015. The cesarean delivery rate in the planned vaginal delivery arm was 49% compared to the cesarean rate of 99% in the planned cesarean delivery arm. If all criteria for vaginal delivery are met, it would be reasonable and appropriate to offer women with diamniotic twin gestations planned vaginal delivery between 34 0/7 to 37 6/7 weeks of gestation.
In this single-arm, open-label, Phase III study of a novel vaginal pH regulator gel among 1,384 sexually active women aged 18 to 35 years, the seven-cycle cumulative pregnancy rate was 13.7% (95% confidence interval, 10.0% to 17.5%).
Recurrent bacterial vaginosis is a problem that affects many women, with an estimated 50% of women developing a recurrence within 12 months of treatment. The authors of this study tested the efficacy of a novel product, Lactobacillus crispatus CTV-05 (Lactin-V), in reducing bacterial vaginosis recurrence in this phase 2b clinical trial.
In this open-label, equivalence randomized trial of vaginal progestogen compared to intramuscular progestogens for preventing preterm birth in high-risk women, the difference in the risk of preterm birth at < 37 weeks of gestation between both groups was 3.1% (95% confidence interval, -7.6% to 13.8%), which was within the equivalence margin of 15% used in the study.
In this randomized, controlled trial of 228 women, Lactobacillus crispatus CTV-05 (Lactin-V) applied vaginally for 11 weeks reduced the incidence of recurrent bacterial vaginosis from 45% in the placebo arm to 30% in the Lactin-V arm.
In a large, cross-sectional, multicenter study in Italy that evaluated factors predictive of sexual dysfunction, vaginal dryness correlated independently and negatively with each Female Sexual Function Index domain.
Annovera is designed for 21 days of continuous use, followed by a seven-day ring-free interval, during which the ring is removed, washed, and stored. Unlike other products, the same ring is used for subsequent cycles for an entire year (13 cycles total).
A post-hoc analysis of data from a 12-week randomized study that compared vaginal estradiol to vaginal moisturizers found no increase in sexual frequency or decrease in pain associated with either treatment, compared to placebo.
In a multicenter, randomized clinical trial, researchers found that a single dose of intravenous amoxicillin/clavulanic acid significantly reduced the risk of infection following operative vaginal birth (forceps or vacuum extraction) compared to placebo (180 of 1,619 [11%] vs. 306 of 1,606 [19%], respectively; P < 0.0001).