Articles Tagged With: variants
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COVID-19: Beware Remdesivir Resistance
Researchers reported two immunosuppressed renal transplant recipients with persistent SARS-CoV-2 infection in association with the new emergence of mutations in RNA-dependent RNA polymerase after remdesivir treatment.
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Genetic Evaluation of Hereditary Spastic Paraplegia
Hereditary spastic paraplegia (HSP) refers to a group of rare, clinically heterogenous degenerative neurogenetic disorders resulting in spasticity, gait impairment, and falls as the result of a length-dependent upper motor neuron degeneration. Next-generation sequencing with multigene panels or exome analysis can confirm molecular diagnosis of approximately 30% of HSP patients. Multigene panels can identify the common causative variants, variants on rarely involved genes, and structural rearrangements.
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Genetic Evaluation of Hereditary Spastic Paraplegia
Hereditary spastic paraplegia (HSP) refers to a group of rare, clinically heterogenous degenerative neurogenetic disorders resulting in spasticity, gait impairment, and falls as the result of a length-dependent upper motor neuron degeneration. Next-generation sequencing with multigene panels or exome analysis can confirm molecular diagnosis of approximately 30% of HSP patients. Multigene panels can identify the common causative variants, variants on rarely involved genes, and structural rearrangements.
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Urgent Need for ‘Universal’ Vaccines for SARS-CoV-2
There is an emerging consensus in the scientific community that is two-fold: COVID-19 is not going away anytime soon, and continuous vaccine boosters eventually could yield diminishing returns. What is needed are new, second-generation vaccines that confer broader immunity against both circulating variants and mutations yet to arise.
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Virus, Variants, Vaccines
The emergence of SARS-CoV-2 variants may compromise the efficacy of current vaccines.
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Evolving Variants, New Vaccines: IPs Must Be Steadfast in Pandemic
Three SARS-CoV-2 variants of global concern now are in the United States, threatening to erode vaccine efficacy, undermine treatment, and increase both hospitalizations and deaths. With vaccine supply limited, masking, social distancing, and hand hygiene will be critical over the next few months.
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Vaccines Threatened, Still Effective Against COVID-19 Variants
Current vaccines are holding against an emerging array of highly transmissible SARS-COV-2 variant strains, but researchers are warning that a somewhat literal “arms race” has begun between immunization science and relentless evolution.
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Emerging Coronavirus Variants Narrow the Margin for Error
A highly transmissible variant of the SARS-CoV-2 virus originally from the United Kingdom is emerging rapidly in the United States, with 76 cases detected in 12 states when this report was filed.
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Emerging Coronavirus Variants Are Highly Transmissible
More transmissible variants of the SARS-CoV-2 virus are emerging globally and had been detected in three U.S. states as this report was filed. The mutated strains do not appear more virulent, but the enhanced transmission narrows the margin of error for breaks in personal protective equipment and other exposures as healthcare workers begin to take their first doses of the COVID-19 vaccines.
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Ethical Obligations to Study Participants if Findings Are of Unknown Significance
The average person carries more than 500,000 rare or novel genetic variants, thousands of which might be identified during a genomics research study. The question is whether, and how, people should be told about any of these findings.