Sepsis remains a major healthcare problem associated with significant morbidity and mortality. Roles for hydrocortisone, ascorbic acid (vitamin C), and thiamine (HAT therapy) as potential adjuvants remain controversial.
A self-report of any vitamin D supplementation is associated with a decrease in colorectal polyps; adjusted odds ratio (aOR) 0.57 (95% confidence interval [CI], 0.33-0.96) in high-latitude conditions. A self report of meeting 600 IU of vitamin D, the recommended daily intake for that region, is associated with a decrease in high-risk adenomatous polyps, with an aOR of 0.78 (95% CI, 0.62-0.99) in high-latitude conditions.
In this randomized, double-blinded, placebo-controlled trial, intravenous vitamin C infusion did not influence a change in the modified Sequential Organ Failure Assessment score from the time of infusion to four days compared to placebo.
In this systematic review and meta-analysis of randomized controlled trials, researchers determined that when compared with placebo or no treatment, vitamin D supplementation alone was not associated with an increase in overall all-cause mortality, though there were some nuances based on vitamin D form and type of mortality.
The authors of this trial investigated the benefits and risks of early anticoagulation following acute ischemic stroke, and compared the effects of direct oral anticoagulants vs. vitamin K antagonists. Overall, treatment with direct oral anticoagulants resulted in a reduced risk of poor clinical outcomes, primarily due to reduced risk of intracerebral hemorrhage.
The Maternal Vitamin D for Infant Growth (MDIG) trial was conducted in Bangladesh to further understand whether prenatal vitamin D with or without postpartum supplementation affects infant growth or other maternal, newborn, and infant outcomes.
This secondary analysis of Effects of Aspirin in Gestation and Reproduction trial found that women with sufficient 25-hydroxyvitamin D levels (≥ 30 ng/mL) were more likely to become pregnant and have a live birth than women with insufficient concentrations of vitamin D.
The authors of this systemic review, random-effect meta-analysis, and trial sequence analysis suggested that vitamin D supplementation does not have clinically significant effects on bone mineral density or the prevention of fractures or falls.
The authors of a systematic review of 13 studies found convincing evidence that vitamin C supplementation, beginning before cardiac surgery and continuing for a few days postoperatively, can decrease the risk of atrial fibrillation.