Internal Medicine Alert – June 30, 2009
June 30, 2009
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Sleep: Is It Overrated?
For patients with chronic insomnia, sleeping pills in combination with cognitive behavioral therapy (CBT) resulted in improved sleep satisfaction during acute therapy, but long- term treatment was enhanced by stopping the medication and continuing only CBT. -
Effectiveness of Beta- blockers in Heart Failure
In elderly patients hospitalized with heart failure and LVSD, beta-blocker use was clinically effective in reducing mortality and rehospitalization, but patients with preserved systolic function had poor outcomes and beta-blockers did not significantly influence the mortality and rehospitalization rate for these patients. -
Should We Perform Serial Ultrasonography to Tailor Anticoagulation Therapy for Patients with DVT?
In patients with proximal deep vein thrombosis (DVT), tailoring the duration of oral anticoagulation based on serial ultrasonography reduces the rate of recurrent DVT. Prolongation of chronic anticoagulation may accelerate vein recanalization. Residual DVT on ultrasonography is a marker of hypercoagulability. -
Iloperidone Tablets (Fanapt™)
Iloperidone is the newest atypical antipsychotic agent to be approved by the FDA. It is chemically similar to risperidone and ziprasidone. Vanda Pharmaceuticals will market iloperidone as Fanapt™. -
Clinical Briefs by Louis Kuritzky, MD
A variety of highly effective agents for primary insomnia are currently available including benzodiazepines, benzodiazepine receptor agonists, and other classes. Agents that impact the benzodiazepine receptors (i.e., either benzodiazepines or benzodiazepine receptor agonists) are controlled substances and have occasional problematic issues such as misuse, diversion, cognitive clouding, and rebound upon withdrawal.