Internal Medicine Alert – March 30, 2019
March 30, 2019
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An Update to the Management of Atrial Fibrillation
This focused update to the 2014 guidelines for the management of atrial fibrillation (AF) includes revisions to anticoagulation recommendations and the role of catheter ablation of AF in patients with heart failure.
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Rethinking the Prophylactic Use of Proton Pump Inhibitors in the ICU
The authors of this multicenter, blinded, randomized trial found that among critically ill adults at risk for gastrointestinal (GI) bleeding, fewer patients in the pantoprazole group exhibited clinically important GI bleeding compared to placebo, although mortality at 90 days was similar in both groups.
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IV to Oral Conversion of Antibiotic Therapy for Bacteremia Due to Enterobacteriaceae
Oral step-down antibiotic therapy (IV to oral conversion) is safe and effective in patients with bloodstream infection due to Enterobacteriaceae.
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Dual Antiplatelet Therapy With Cilostazol for Secondary Stroke Prevention (LB3)
In a recent trial, patients treated with dual antiplatelet therapy combining cilostazol with either aspirin or clopidogrel were at a lower risk of ischemic stroke recurrence and at a similar risk of significant bleeding compared to patients treated with aspirin or clopidogrel alone.
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Ripples From Original WHI Study Results Continue: Is This Appropriate?
Recommendations for menopausal hormone therapy were widely publicized and adopted following the original publication of the results of the Women’s Health Initiative, affecting both initiation and continuation of estrogen therapy through at least 2013.
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PrabotulinumtoxinA-xvfs Injection (Jeuveau)
PrabotulinumtoxinA-xvfs is indicated for temporary improvement in the appearance of moderate to severe glabellar lines associated with corrugator and/or procerus muscle activity in adults.