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November 22, 2022

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  • FISH Adequate to Follow CML after Response

    Chromosome banding analysis (CBA) of marrow metaphase cells is the standard method to assess response in CML. The authors compared CBA to interphase fluorescence in situ hybridization (I-FISH) in 664 samples where both methods were performed.
  • Quality of Life in Long-term Survivors of Hodgkin's Lymphoma

    A long-term longitudinal assessment of quality of life among patients treated for early-stage Hodgkin's lymphoma reveals that, with the exception of fatigue, there is general improvement over time. Factors that influence the rate of improvement include age and sex, but do not include the type of treatment received (radiation vs. chemotherapy).
  • Physical Activity and Prostate Cancer

    In a large population-based, prospective cohort study, it was found that spending less than 50% of the day in a sedentary position, and increasing amounts of physical activity (e.g., walking or bicycling) appear to be associated with reduced rates of prostate-cancer development.
  • The Importance of Lymph Node Status After Neoadjuvant Therapy for Rectal Cancer

    In a retrospective tumor registry (SEER) analysis of outcomes for rectal-cancer patients treated over a 14-year period with either presurgical or postsurgical radiation therapy, the importance of pathological lymph node status was found to be significantly more adverse for patients who had presurgical treatment. These patients define a subgroup for whom aggressive post-surgical treatment would seem warranted.
  • Depression and Cancer

    This meta-analysis revealed overall increased mortality of up to 25% in patients experiencing depressive symptoms after cancer diagnosis, and a 39% higher risk in patients diagnosed with major or minor depression after cancer diagnosis, based upon 25 independent studies. Given the low number of studies available to date, the effect of depressive symptoms on cancer recurrence did not reach a level of statistical significance.
  • Clinical Briefs in Primary Care Supplement

  • Pharmacology Watch

    Statin and niacin increase HDL-C, omeprazole reduces effectiveness of clopidogrel, darbe-poetin increases risk of stroke, statins decrease risk of gallstone disease, FDA Actions.