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These authors analyzed data from a long-standing prospective cohort to study changes in prescribing habits and pregnancy outcomes following restriction on the use of valproic acid in women of child-bearing potential. Declining use of valproate and carbamazepine was associated with a decline in teratogenesis.
Patients with cirrhosis and mild cognitive impairment and falls were randomized to a probiotic formulation vs. placebo. Probiotic treatment improved cognitive outcomes and reduced the risk of falls.
In a large Italian database-derived, case-control study of dietary and environmental factors, antecedent infections and diet appeared to influence the onset and course of chronic inflammatory demyelinating polyradiculoneuropathy. The diagnosis and treatment of this disorder remain a challenge.
In this prospective longitudinal study investigating the potential mechanistic link between adiposity and vascular cognitive impairment, anthropometric and metabolic hormone adiposity predictors were differentially associated with cerebrovascular and brain volumetry outcomes by sex in older individuals.
In a comprehensive review of published literature and meta-analysis of clinical trials of acute spinal cord injury treatment with high-dose steroids within eight hours of onset, the authors concluded that there is no benefit regarding neurological recovery and function and an increased risk of adverse side effects from gastrointestinal bleeding.
Bridging therapy with intravenous thrombolysis appears to be associated with improved functional outcome without any additional complications compared to direct mechanical thrombectomy for patients with acute ischemic stroke who have LVOs.
Financial Disclosure: Neurology Alert’s Editor in Chief Matthew Fink, MD; Peer Reviewer M. Flint Beal, MD; Editorial Group Manager Leslie Coplin; Executive Editor Shelly Morrow Mark; and Accreditations Manager Amy M. Johnson, MSN, RN, CPN, report no financial relationships relevant to this field of study.
