Are Oral Corticosteroids as Effective as Intravenous Steroids in the Treatment of Acute Optic Neuritis?

Based on outcomes measured at one and six months following optic neuritis in the context of multiple sclerosis, these investigators reported similar efficacy when comparing oral to bioequivalent doses of intravenous steroids.

Viral Therapy for Glioblastoma

In a Phase I/II trial, convection-enhanced delivery of an engineered poliovirus yielded similar median overall survival compared to historical controls. However, a small subgroup of treated patients had extended survival past two years.

Use of Amyloid PET Imaging for Diagnosis of Dementia

The use of amyloid positron emission tomography scanning to assist in accurate diagnosis of patients with symptoms of cognitive impairment as well as frank dementia results in a change of diagnosis in at least 25% of patients.

Predicting Future Dementia With Retinal Optical Coherence Tomography

Optical coherence tomography (OCT) is an innovative imaging device that measures thickness of retinal nerve fiber layers and ganglion cells. Thinning of these layers is associated with current and future risk of dementia.

Untangling the Factors Governing Huntington’s Disease Progression

In a study of more than 3,000 subjects, CAG-repeat-dependent factors affecting age at onset also influenced rates of progression of cognitive, motor, and functional impairments, providing optimism that developing interventions, such as gene silencing therapies, could provide benefit.