Neurology Alert – January 1, 2003
January 1, 2003
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Do Dietary Antioxidants Prevent Alzheimer’s Disease?
Three recent studies have provided epidemiologic data that increased intake of antioxidants may be associated with a reduced risk of developing AD. -
Fibrates, Statins, and Myopathy
Fibrates and statins are associated with a 42-fold and 8-fold increased risk of myopathy, respectively, compared to normal controls, but the incidence remains low, at 6 per 100,000 and 1 per 100,000, respectively. -
Dopamine Agonists for Parkinson’s Monotherapy
In this thoughtful, well-balanced review, Clarke and Guttman review the evidence for using new dopamine agonists to treat patients with early PD. -
Alzheimer’s Vaccination Re-Examined
The results of 3 recent investigations suggest that immunotherapy still has the potential to become a treatment for AD but that the road to its successful development is likely to be a long one. -
Warfarin vs Aspirin in AF: A Meta-Analysis
Considerable concern exists among clinicians regarding the risk-benefit ratio of long-term anticoagulation compared to antiplatelet treatment. In order to compare the risk of vascular events and bleeding complications in patients with AF, van Walraven and associates analyzed data from 6 randomized clinical trials. -
Late Breakers
Aripiprazole (Abilify), a new drug for schizophrenia, received FDA approval November 15; on November 14, Neurocrine Biosciences Inc. announced positive results from its first phase III clinical trial with indiplon-IR achieving primary and secondary end points of sleep initiation. -
Pharmacology Watch: FDA Approves Claritin For OTC Use For Seasonal Rhinitis
FDA Approves Claritin For OTC Use For Seasonal Rhinitis; Simpler Atrial Fibrillation Management; Oral Anticoagulation Vs Aspirin in AF; Immunization Does Not Cause Autism; Statins May Lower CRP Levels; Simvastatin Reduced CRP Plasma Levels; FDA Actions -
Clinical Briefs in Primary Care Supplement
Effects of Losartan on Cardiovascular Morbidity and Mortality in Patients with Isolated Systolic Hypertension and LVH; Increase in Nocturnal Blood Pressure and Progression to Microalbuminuria in Type 1 Diabetes; HRT, Lipid, and Glucose Metabolism in Diabetic and Nondiabetic Postmenopausal Women; Effects of Long-Term Treatment With ACE Inhibitors in the Presence or Absence of Aspirin; Long-Term Risks Associated with Atrial Fibrillation: 20-Year Follow-up of the Renfrew/Paisley Study; Olfactory Impairment in Older Adults