Painful Legs and Moving Toes: How to Diagnose and What to Do?

Fourteen cases of the rare and difficult to treat "painful legs and moving toes" syndrome are presented. The cases included diverse etiologies—polyneuropathy, radiculopathy, or neuroleptic use—and half responded to GABAergic medications.

IV Valproic Acid vs Phenytoin: Old Standby or the New Challenger?

Valproic acid and phenytoin were equally effective in the treatment of acute repetitive seizures and status epilepticus.

Carotid Arterial Dissection: Time for a Randomized Clinical Trial

There are no randomized controlled treatment trials of cervical artery dissection, and the most effective therapy is uncertain.

A Neurophysiology Study: Thalidomide and Sensory Neurotoxicity

Axonal sensory neuropathy is a common complication of thalidomide therapy and occurs at a lower than expected dose in patients with cutaneous lupus.

Needle Electromyography: Hemorrhagic Risks and Complications

Needle EMG is a safe procedure in patients who are taking antiplatelet or warfarin therapy.

Anxiety in Parkinson's Disease: Diagnostic Evaluation and Pitfalls

Anxiety is a common but underrecognized symptom of Parkinson's disease, for which there are a number of suggested but no recommended rating scales.

Pharmacology Watch

5-α reductase inhibitors and hip fracture in men; the effects of drug-reimbursement policy on outcomes; new guidelines for type 2 diabetes; beta-blocker-associated brady-cardia is linked to CVD events; FDA Updates.

Clinical Briefs in Primary Care supplement

December 1, 2008