Pharmacology Watch – January 1, 2018
January 1, 2018
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Is Ibuprofen Plus Acetaminophen as Effective as Opioids?
The authors of a recent analysis concluded that for patients presenting to the ED with acute extremity pain, there were no statistically significant or clinically important differences in pain reduction at two hours among single-dose treatment with ibuprofen and acetaminophen or three different opioid/acetaminophen combination.
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Direct-acting Oral Anticoagulants vs. Warfarin in Atrial Fibrillation
Direct-acting oral anticoagulants are superior to warfarin for stroke prevention in atrial fibrillation, according to a new review.
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Does Warfarin Prevent Cancer?
The finding that warfarin lowers the risk of cancer is plausible because warfarin inhibits AXL receptor tyrosine kinase-dependent tumorigenesis and enhances antitumor immune responses, even at doses below anticoagulation levels.
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FDA Actions
In this section: FDA approves treatment for opioid use disorder, greenlights product to reduce cardiovascular events, gives the go-ahead to the eighth biosimilar, and approves a two-drug HIV regimen.