Bacterial Infections
RSSArticles
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Shigella: The New Superbug?
Five percent of Shigella isolates in the United States in 2022 were extensively drug-resistant.
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Golden State: Disseminated Gonococcal Infection
The diagnosis of disseminated gonococcal infection often is delayed, but the infection can most often be readily treated with ceftriaxone. Patients often lack urogenital symptoms.
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Dual Therapy Using Doxycycline and Azithromycin Is Superior to Monotherapy for Treating Severe Scrub Typhus
A multicenter, randomized, double-blind, controlled trial from India found dual therapy with intravenous doxycycline and azithromycin is more effective than either agent alone for treating severe scrub typhus.
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Immortal Time Bias and Mortality Effects of 18F-FDG-PET/CT in Patients with Staphylococcus aureus Bacteremia
Staphylococcus aureus bacteremia is associated with high mortality and often is complicated by metastatic sites of infection that can be difficult to identify and control. Fluorine-18 fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography has shown promise in some observational studies as an important diagnostic modality for detecting foci of infection and potentially guiding clinical management in ways that may lead to improved outcomes, including lower mortality. The validity of these findings has been questioned, however, due to the risk of significant bias.
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A Rapid Molecular Test Improves Time to Appropriate Therapy and Mortality in Patients with CRE Bacteremia
A multicenter observational study of patients with carbapenem-resistant Enterobacterales bacteremia found that time to receipt of active antibiotic therapy and mortality were improved in those whose blood cultures underwent rapid molecular testing for the Klebsiella pneumoniae carbapenemase gene. The mortality rate was 10% with ceftazidime-avibactam compared to 31% with polymyxin monotherapy.
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Nationwide Outbreak of Extensively Drug-Resistant Pseudomonas aeruginosa Infections from Contaminated Eye Drops
An outbreak of extensively drug-resistant Pseudomonas aeruginosa infection has been traced to use of contaminated artificial tears.
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Comparison of Postoperative Antibiotic Regimens for Complex Appendicitis: Is Two Days as Good as Five Days?
In a pragmatic, open-label, randomized trial conducted at 15 hospitals in the Netherlands, two days of postoperative intravenous antibiotics for complex appendicitis was found to be noninferior to five days in terms of infectious complications and mortality within 90 days.
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Infectious Disease Alert Updates
California Firefighters at Risk for Cocci; Hyperglycemia and Diabetes with INSTIs; Positive Sputum in Extra-Pulmonary Tuberculosis
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A Comparison of Ceftaroline and Daptomycin in Treatment of MRSA Bloodstream Infections
Ceftaroline is an acceptable alternative therapy for treatment of methicillin-resistant Staphylococcus aureus bacteremia.
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Infectious Disease Alert Updates
Is Your Hospital Room Toxigenic?; Reduction of HOCDI — Gaming the System?