Bacterial Infections
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Fecal Microbiota, live-jslm (Rebyota)
Rebyota can be prescribed to prevent recurring Clostridioides difficile infection for patients age 18 years and older who are following antibiotic treatment for recurring episodes.
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When More Is Not Better: Treatment of Prosthetic Valve Endocarditis Due to Staphylococci
Clear evidence of benefit from adjunctive administration a β-lactam and/or a glycopeptide in the treatment of prosthetic valve endocarditis due to staphylococci is lacking. Current guidelines need to be reassessed.
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It’s Not All About the Cough
Be careful about relying on clinical queries that focus on the presence of cough for two or more weeks, which could lead to delays in the diagnosis of nearly half of pulmonary tuberculosis cases.
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WHO Lobbies for Updated Tuberculosis Vaccines
International organization says these investments could drive economic growth, improve health equity and antimicrobial stewardship, and lower mortality rates.
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Limiting Testing in Febrile Young Infants with Abnormal Urinalyses
According to a 26-site study, febrile infants younger than 2 months of age who have abnormal urinalyses are at very low risk of having meningitis and might not necessarily need to be subjected to lumbar puncture.
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Disseminated Infection Due to Neisseria gonorrhoeae
Only 0.24% of patients with gonorrhea had disseminated infection, with septic arthritis occurring in approximately one-half.
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Multi-State Tuberculosis Outbreak Due to Transmission from an Infected Bone Graft Product
An 80-year-old man with undiagnosed tuberculosis (TB) became a bone tissue donor after his death from a cardiac arrest. Bone graft product was given to 113 recipients in 20 states, of whom three died of TB. All living recipients were started on treatment for TB at a median of 69 days after bone product implementation.
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Better Diagnostics Equals Fewer Unnecessary Antibiotic Prescriptions
Researchers credit diagnostic stewardship as the top reason for an impressive reduction in needless antibiotic prescriptions.
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Cellular Tests Are Not Accurate for Diagnosing Lyme Disease
A prospective case-control study from the Netherlands evaluated three cellular tests for diagnosing Lyme disease. All three had low specificity compared to serological testing, leading to an unacceptably high number of false-positive results.
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Antibiotic Resistance: We Were Doing Great and then COVID Happened
After improvement, antimicrobial resistance in the United States significantly increased.