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This widely publicized small trial has catapulted the mutant form of ApoA-1 Milano into the limelight. Many investigators have been working with this interesting lipoprotein since it was discovered in the 1980s that 38 carriers from a small village in Northern Italy have very low HDL levels but very little vascular disease.
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Oral rofecoxib (Vioxx) may have a role in controlling postoperative pain patients undergoing knee surgery.
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In patients with acute anterior myocardial infarction the significance of inferior ECG ST-segment elevation is unclear. Thus, investigators from the GUSTO-I angiographic and the GUSTO-IIb angioplasty substudies evaluated the 1046 patients with anterior ST elevation and divided them into 3 groups.
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Talreja and colleagues from the Mayo Clinic in Rochester, Minn, reviewed biopsy specimens and clinical features of 143 patients who had pericardiectomy for proven pericardial constriction.
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In this paper from 2 Italian centers, Pappone and colleagues report the results of a randomized trial of prophylactic catheter ablation in previously asymptomatic patients with Wolff-Parkinson-White syndrome.
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The Prevention of Atrial Fibrillation After Cardioversion Trial was a placebo-controlled study comparing sotalol and a quinidine/verapamil combination in patients with persistent atrial fibrillation after cardioversion.
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Low-dose aspirin is as effective as warfarin for preventing cerebral thromboembolic events after bioprosthetic aortic valve replacement.
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The developing world is experiencing an epidemic of CAD which expects to continue to increase in the foreseeable future.
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The use of automatic external defibrillators by trained volunteers is safe and effective, particularly in public locations where there is at least a moderate likelihood that an out-of-hospital cardiac arrest will be witnessed.
