Clinical Publication
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New Guidance to Promote Diverse Populations in Cardiovascular Trials
Individuals who participate in randomized clinical trials should be representative of the patients who will be treated with the drugs under investigation. Unfortunately, studies have consistently shown women and those from racial and ethnic minority groups are consistently underenrolled in cardiovascular clinical trials relative to their disease burden in the population.
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Investigators Make Ethical Commitment for Neuroscience Research in Humans
There are overarching principles of ethical conduct of human neuroscience research, but the methods and implementations may vary across institutions.
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Ethics Training for Community-Engaged Research in Latino Community
Researchers recently provided human research ethics training to community health workers who were studying the effect of an intervention to promote healthy behaviors and expand healthcare access among Latinos.
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Use Caution if Machine Learning Models Are Used to Predict Mortality
Machine learning and artificial intelligence will be part of caring for patients in some way or another going forward. Clinicians need to know what it all means and what the potential pitfalls are.
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Ethical Controversy Persists Over Organ Procurement Method
Ethical debate continues over a controversial method of procuring organs for transplantation: Normothermic regional perfusion with controlled donation after circulatory determination of death.
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Greater Awareness of Reporting Bias on Antidepressants, Yet Problem Persists
An investigator who was part of a landmark study on the efficacy of antidepressants recently revisited reporting transparency in this area of research.
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Regarding Exercise Capacity Past Age 75 Years, What Is Normal?
A group of researchers delivered results that could help inform clinicians about the expected exercise test performance of older patients.
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Detecting Cancer Treatment-Related Cardiac Dysfunction
When searching for breast cancer-related cardiac dysfunction, a sequential algorithm using echo ejection fraction and strain parameters produced an area under the receiver operating curve of 89%. Adding biomarkers did not improve the ability to diagnose cardiac dysfunction.
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Comparing CT Angiography to Invasive Angiography for Stable Chest Pain Patients
A trial of initial coronary CT angiography vs. invasive angiography revealed outcomes over a median 3.5-year follow-up were similar, but procedure-related complications were more common in the invasive group.
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Thrombolysis vs. Surgery for Thrombosed Mechanical Prosthetic Valves
A study of patients with obstructive prosthetic valve thrombosis that deployed low-dose, slow infusion thrombolysis or surgery using shared decision-making, showed thrombolysis was highly effective and resulted in fewer major complications than surgery.