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Kiso and colleagues in Japan collected serial upper respiratory tract samples from children receiving oseltamivir for treatment of influenza A (H3N2), for isolation of the virus. Mutations in neuraminidase were identified in virus obtained from from 9 of 50 (18%) immunocompetent children treated with oseltamivir. Eight of the 9 contained mutations previously identified as conferring resistance to oseltamivir, while the ninth had a novel mutation.
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A 38-year-old man returned to the United States from west Africa, where he had spent the last 4 months in Liberia and Sierra Leone where he owned farms. Two days before his August 2004 return, he developed fever, chills, and severe sore throat, and shortly after his arrival, he was hospitalized with, in addition to these complaints, diarrhea and back pain. Lassa fever was considered, and administration of ribavirin was planned, but the patient died before receiving this antiviral medication. The diagnosis of Lassa fever was confirmed by serum antigen detection, immunohistochemical staining of postmortem liver tissue, virus isolation in cell culture, and genome sequencing.
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A retrospective review of 1387 cases of salmonellosis revealed that almost half of cases in children younger than 5 years of age were associated with contact with a reptile.
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Overall, caspofungin was at least as effective as liposomal amphotericin B for empiric therapy in persistently febrile neutropenic patients. Caspofungin therapy was associated with greater survival 7 days after the end of therapy, greater efficacy in treatment of baseline fungal infections, and it was better tolerated.
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Cockerill and colleagues examined the effects of the volume of blood, the number of consecutive blood culture specimens, and the incubation time on the recovery of pathogens from 37,568 blood cultures obtained from adults. The study was performed at the Rochester, MN Mayo Clinic from 1996 to 1997, and used the automated BACTEC 9240 instrument.
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Bed Bugs Are Back; Can You Guess the Pathogen?; If It Was a Bear, It Would Have; More Bites.
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Bacteriologic and clinical failures in adults with Streptococcal tonsillopharyngitis are twice as likely with oral penicillin therapy as with cephalosporin treatment. But, what is the significance of this finding?
