OB/GYN Clinical Alert
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How Common Is Cardiovascular Disease in Pregnant and Postpartum Women from Socioeconomically Disadvantaged Backgrounds?
Neighborhood-level socioeconomic inequities in early pregnancy were associated with higher risk of long-term cardiovascular disease in pregnant and postpartum women.
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Maternal Mortality in the United States Is Worse than in any Other High-Income Nation
This article compares U.S. maternal mortality to other nations and explores reasons why mortality in the United States is four to 10 times higher than in peer countries.
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Furosemide for the Management of Postpartum Hypertension
Current evidence does not support the effectiveness of furosemide in reducing the mean arterial pressure within 24 hours before discharge from delivery hospitalization or before starting antihypertensive medications, compared to a placebo.
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What Do Clinicians Think About the American Cancer Society Cervical Cancer Screening Guidelines?
In this study of provider attitudes toward the American Cancer Society 2020 cervical cancer screening guidelines that recommend deferring screening until age 25 years and using human papilloma virus alone as the primary screening, most providers had not adopted the guidelines and were waiting for endorsement by other professional societies, such as the American College of Obstetricians and Gynecologists and the American Society for Colposcopy and Cervical Pathology.
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Targeting Vasomotor Symptoms with a Neurokinin-3 Receptor Antagonist
A meta-analysis of five randomized controlled studies showed that fezolinetant improved moderate-to-severe vasomotor symptoms with a pooled mean difference of 2.62 episodes per day (95% confidence interval [CI], 1.85-3.41) and had no significant adverse effects compared to placebo (odds ratio, 1.01; 95% CI, 0.84-1.22).
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Safety of Non-Insulin Antidiabetic Medications in Early Pregnancy
A multinational cohort study of more than 50,000 pregnant people found that those with periconceptual use of non-insulin antidiabetic medications, such as sulfonylureas, dipeptidyl peptidase 4 inhibitors, glucagon-like peptide 1 agonists, or sodium-glucose cotransporter 2 inhibitors, did not have increased risk of congenital malformations compared to those who used insulin periconceptually.
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Estradiol Valerate-Dienogest and VTE Risk in Combined Oral Contraceptives
A pooled analysis comparing the risk of venous thromboembolism associated with combined oral contraceptives (COC) found significantly decreased venous thromboembolism risk in estradiol valerate-dienogest COCs compared with ethinyl estradiol-levonorgestrel COCs (propensity score-stratified hazard ratio, 0.46; 95% confidence interval, 0.22-0.98).
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Progestins and Meningioma Risk: What Do the Data Say?
The authors of this study sought to determine whether there was a relationship between progestins and central nervous system meningiomas.
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Medication Abortion via Telehealth in the United States
A prospective study of U.S. patients obtaining medication abortion through telehealth platforms demonstrated high effectiveness (97.7%; 95% confidence interval [CI], 97.2% to 98.1%) and safety (99.8%; 95% CI, 99.6% to 99.9%).
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The Role of Probiotics and Synbiotics for Management of Gestational Diabetes
Probiotics and synbiotics have shown promise in reducing insulin resistance and enhancing glycemic control, blood lipid profiles, and inflammation among women with gestational diabetes mellitus (GDM). Although they hold potential as a treatment option for GDM, conclusive recommendations await larger, well-designed randomized controlled trials with extended follow-up periods.