Pharmacology Watch
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No Association Between Vitamin D, Calcium Supplements and Fracture Prevention in Older Adults
There were no significant associations between calcium, vitamin D, or combined calcium and vitamin D supplements or the incidence of nonvertebral, vertebral, or total fractures. The results were consistent regardless of the dose of vitamin D or calcium, sex, fracture history, dietary calcium intake, or baseline serum 25-hydroxyvitamin D concentration.
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Is There a Connection Between Breast Cancer and Hormonal Contraceptives?
In a recent study, the authors concluded that while the risk is small, there was a higher risk of breast cancer among women who currently or recently used contemporary hormonal contraceptives than among women who had never used hormonal contraceptives.
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FDA Actions
In this section: FDA approves treatment for opioid use disorder, greenlights product to reduce cardiovascular events, gives the go-ahead to the eighth biosimilar, and approves a two-drug HIV regimen.
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Does Warfarin Prevent Cancer?
The finding that warfarin lowers the risk of cancer is plausible because warfarin inhibits AXL receptor tyrosine kinase-dependent tumorigenesis and enhances antitumor immune responses, even at doses below anticoagulation levels.
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Direct-acting Oral Anticoagulants vs. Warfarin in Atrial Fibrillation
Direct-acting oral anticoagulants are superior to warfarin for stroke prevention in atrial fibrillation, according to a new review.
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Is Ibuprofen Plus Acetaminophen as Effective as Opioids?
The authors of a recent analysis concluded that for patients presenting to the ED with acute extremity pain, there were no statistically significant or clinically important differences in pain reduction at two hours among single-dose treatment with ibuprofen and acetaminophen or three different opioid/acetaminophen combination.
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FDA Actions
In this section: FDA approves new herpes zoster vaccine, greenlights second gene therapy for cancer, and issues warnings to companies marketing cannabidiol.
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Rivaroxaban Plus Aspirin for Secondary Prevention
Among patients with stable cardiovascular disease, those assigned to rivaroxaban plus aspirin in a recent study experienced better cardiovascular outcomes and more major bleeding events than those assigned to aspirin alone. Rivaroxaban alone was no better than aspirin.
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Monitoring Bleeding Risks Associated With Non-vitamin K Oral Anticoagulants
In a recent trial, among patients taking non-vitamin K oral anticoagulants for atrial fibrillation, concurrent use of amiodarone, fluconazole, rifampin, and phenytoin was associated with increased risk of major bleeding.
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Lowering Dementia Risk in Atrial Fibrillation Patients
Oral anticoagulants may reduce the risk of dementia in patients with atrial fibrillation, according to a new study from Sweden.