Aliskiren and ACEIs/ARBs don't mix

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January 2, 2015

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Aliskiren and ACEIs/ARBs don't mix

Aliskiren (Tekturna), Novartis' direct renin inhibitor, should not be combined with an ACE inhibitor or angiotensin receptor blocker (ARB) to treat hypertension, according to the manufacturer. Novartis recently terminated the ALTITUDE trial when it was found that patients with type 2 diabetes or impaired renal function who were given the combination of aliskiren with an ACEI or ARB had a higher incidence of nonfatal stroke, renal complications, hyperkalemia, and hypotension. More information can be found at www.novartis.com/newsroom/media-releases/en/2011/1572562.shtml.

Post Date: January 2, 2015

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