Administering trastuzumab after a course of anthracycline therapy for breast cancer can result in cardiac toxicity. Serial echocardiograms in this study showed that a lower initial left ventricular ejection fraction before anthracycline therapy and the amount of decrease in ejection fraction after the anthracycline course are predictive of subsequent trastuzumab cardiac toxicity.
In a pooled analysis of prospective studies, researchers found an increased risk of breast cancer among parous women that persists for more than 20 years after childbirth. Breastfeeding did not modify this pattern.
Large study includes all forms of current hormonal contraception
December 28, 2017
Results from a study of 1.8 million Danish women ages 15-49 indicate that the risk of breast cancer is increased among women who currently or recently used contemporary hormonal contraceptives compared to those women who have never used such methods. While the risk increased with longer use, the absolute increases in risk were small.
Using data from the Two Sister Study, investigators found no association of past combined hormone replacement therapy with young-onset (before age 50) breast cancer, and a protective effect with estrogen-only therapy.
A new study reports that the incidence of breast cancer is higher in counties with high rates of mammography screening, but screening is not associated with a decrease in breast-cancer deaths. The decision of whether and how often to perform mammography requires a discussion of the potential consequences of both true positive and false positive screening tests.
A large prospective cohort study of perineal talc use demonstrated no increased risk of ovarian cancer overall or within any histological subtype. In addition, no association with talc application method was observed.
According to this pharmacokinetic study, the cyclic use of 20 mcg ethinyl estradiol oral contraceptives is problematic for obese women. Ovarian activity was better suppressed with continuous use (omitting the hormone-free interval) of the same dose oral contraceptive or increasing to a higher dose 30 mcg ethinyl estradiol oral contraceptive