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ACEI/ARB therapy for AS; safety alert issued for dronedarone; statins and cancer risk; nesiritide and heart failure; and FDA actions.
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The echocardiographic assessment of diastolic function of the left ventricle (LV) involves five measurements derived from two-dimensional imaging, pulsed Doppler, Color M-mode, and tissue Doppler. Not only is it complicated, but sometimes the measurements are discordant.
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Computed tomography (CT) imaging has progressed substantially in recent years, and we are now able to non-invasively image coronary artery disease in many patients.
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In this study, the authors attempt to develop a risk stratification score to predict bleeding in patients treated with warfarin oral anticoagulation.
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In patients with severe valvular aortic stenosis (AS), ascending aortic dilatation is common, and is thought to be due to the alterations in flow caused by the stenotic valve.
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The Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) study showed that in patients with stable coronary artery disease (CAD) put on optimal medical therapy (OMT) that randomization to a percutaneous coronary intervention did not improve survival or prevent myocardial infarction.
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The authors conclude that even short-term treatment with most NSAIDs was associated with increased risk of death and recurrent MI in patients with prior MI. Neither short- nor long-term treatment with NSAIDs is advised in this population, and any NSAID use should be limited from a cardiovascular safety point of view.
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Two new drugs for treatment of hepatitis C; NSAIDs and myocardial infarction risk; AIM-HIGH clinical trial stopped; and FDA actions.
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In this paper, Haines and his coauthors propose a scoring system to predict risks associated with implantable cardioverterdefibrillator (ICD) implant procedures.