Clinical decision support (CDS) is meant to improve care quality by providing helpful alerts and advice to the electronic health record user. However, too often the result is an annoying proliferation of pop-ups that only frustrate clinicians. When the CDS system interrupts too much with alerts that are not useful, the result can be counterproductive. Clinicians routinely dismiss alerts. In the process, they may ignore those alerts that are useful, say researchers and hospital leaders.