This was a multicenter, blinded, parallel-group, randomized trial of mechanically ventilated critically ill patients. Achieving 100% calorie requirements did not change outcomes at six months when compared to a more modest goal of 70% of predicted calorie requirements.
Compared to saline, balanced crystalloids reduced in-hospital mortality and major adverse kidney events within 30 days in critically ill patients with sepsis or septic shock.
When the early use of continuous infusion dexmedetomidine was compared to usual care for sedation in mechanically ventilated critically ill adults, there was no difference in 90-day mortality. Dexmedetomidine may not be an ideal sedative for mechanically ventilated critically ill adults requiring deeper sedation, although its use may result in greater ventilator-free, coma-free, or delirium-free days.
