Articles Tagged With: duration
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The Limits of Shortened Antiplatelet Therapy in Acute Coronary Syndrome
One month of dual antiplatelet therapy (DAPT) followed by clopidogrel monotherapy did not meet criteria for noninferiority vs.12 months of DAPT for a composite endpoint of ischemic and bleeding events.
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Antibiotic Therapy: How Long Is Long Enough?
The CDC and the American College of Physicians have provided advice on the best practice regarding the duration of antibiotic therapy for several common infections. -
Antibiotics: Less Is Better, Sometimes
In England, and likely in many other areas of the world, antibiotics are given for longer than necessary. Excessively long durations of antibiotic use do not help patients and risk leading to more resistant infections.
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Rapid Eye Movement Sleep Duration Is Predictive of Life Expectancy
Total sleep duration declines with increasing age, as does the fraction of sleep spent in rapid eye movement (REM) sleep. The decline in REM is associated with increasing mortality, but it is not clear if this is a cause or a marker of declining health and declining brain function.
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Estrogen Replacement: Is Long Duration of Therapy Good for the Brain?
Longer lifetime exposure to endogenous estrogen and menopausal estrogen replacement were associated with better cognitive status in older adult women. Women who initiated estrogen therapy early (within five years of the onset of menopause) showed higher cognitive test scores than those who started later.
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Longer Antibiotic Courses for Pneumonia Do Not Improve Outcomes, But Cause More Adverse Effects
Two-thirds of general medicine patients with pneumonia received excess antibiotic therapy, with 93.2% of the unnecessary duration occurring after hospital discharge. Excess antibiotic therapy did not improve mortality or morbidity outcomes, although each additional antibiotic day was associated with 3% increased odds of antibiotic-associated adverse drug events.
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Seven Days of Antibiotics Was Noninferior to 14 Days for Gram-Negative Rod Bacteremia
In patients with gram-negative rod bacteremia, patients receiving seven days of antibiotics had similar 90-day mortality, readmission rates, and rates of recurrent bacteremia as patients receiving 14 days of antibiotic.
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Treatment of Gram-Negative Bacteremia: How Long Is Long Enough?
Antibiotic administration for seven days is sufficient in stable patients with Gram-negative bacteremia.
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Clinicians Prescribe Antibiotics for Excessive Duration in Patients With a Diagnosis of Acute Sinusitis
Clinicians inappropriately prescribe antibiotics most often to patients with a diagnosis of acute sinusitis for durations much longer than recommended.