Articles Tagged With: endocarditis
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Staphylococcal Prosthetic Valve Endocarditis: Drop the Rifampin? And the Gentamicin?
In a retrospective study, the investigators failed to find evidence of benefit of adjunctive rifampin therapy in patients with staphylococcal prosthetic valve endocarditis. -
Candida Endocarditis
A review of a national administrative database examined 703 patients with Candida endocarditis and found the greatest risk factor for mortality was underlying liver failure, while a history of opiate abuse was associated with a reduced risk of death.
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Ventricular Assist Device Infections: More Questions Than Answers?
Almost two-fifths of patients with left ventricular assist devices develop associated infections. The optimal appropriate management remains to be determined.
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The Risk of Endocarditis With Bacteremia
Interrogation of the Danish National Patient Registry revealed bacteremia due to Enterococcus faecalis was most likely to be associated with infective endocarditis; thus, echocardiography is warranted in these patients.
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The Risk of Endocarditis With Bacteremia
Interrogation of the Danish National Patient Registry revealed bacteremia due to Enterococcus faecalis was most likely to be associated with infective endocarditis; thus, echocardiography is warranted in these patients.
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Cefazolin and Ertapenem as Salvage Therapy in Methicillin-Susceptible Staphylococcus aureus Bacteremia
Cefazolin (CZ) and ertapenem combination therapy was successfully used to salvage 11 cases of persistent methicillin-susceptible Staphylococcus aureus bacteremia. Modest in vitro synergy between CZ and ertapenem was demonstrated on testing of six clinical isolates, but in vivo activity appeared more potent in an animal model than as predicted by in vitro activity.
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Value of PET Scans in Infective Endocarditis
18F-FDG PET/CT imaging in a consecutive series of patients with proven infective endocarditis was of diagnostic value in those with prosthetic value endocarditis and of prognostic value in all cases.
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Trimethoprim Sulfamethoxazole Plus Clindamycin for Treatment of Staphylococcus aureus Endocarditis
A before-and-after intervention study compared 170 patients treated with either oxacillin IV or vancomycin IV for six weeks (plus gentamicin IV given during the first five days) to 171 patients who were treated with TMP/SMZ IV plus clindamycin IV for the first week followed by TMP/SMZ PO (without clindamycin) to complete a six-week course. Mortality and hospital length of stay were significantly less in the TMP/SMZ-treated patients.
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Infective Endocarditis Prevalence in Dutch Patients With Positive Blood Cultures
Data from a nationwide registry in Denmark from 2010 to 2017 showed that patients with Enterococcus faecalis bacteremia had the highest prevalence of infective endocarditis (16.7%), followed by Staphylococcus aureus (10.1%) and Streptococcus spp. (7.3%).
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IV to Oral Antibiotic Switch for Selected Cases of Endocarditis
Completion of therapy of selected patients with infective endocarditis with orally administered antibiotics is feasible, safe, and effective.