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Articles Tagged With:

  • Early Respiratory Decline in Amyotrophic Lateral Sclerosis

    Hypercapnia, a manifestation of early respiratory dysfunction, can be challenging to detect in amyotrophic lateral sclerosis (ALS) patients. Pulmonary function tests are helpful, but their specificity in detecting hypercapnia is low and their use is limited in patients with bulbar weakness. Specific symptoms, such as dyspnea at rest, dyspnea while talking, and use of medications for sleep, can be more reliable in detecting hypercapnia among ALS patients.

  • Atypical Presentations for Inclusion Body Myositis

    Inclusion body myositis, the most common acquired myopathy, often is misdiagnosed or diagnosed after a delay of many years. Atypical presentations are not unusual, and clinicians should maintain a high degree of suspicion for this disorder when patients present with slowly progressive muscle weakness in an unusual pattern.

  • Influence of Vitamin Intake on the Prevalence of Migraine

    In a large population-based survey, 21.6% of participants reported having severe headaches or migraine. Those reporting severe headaches also reported a lower intake of thiamine and riboflavin, based on 24-hour recall of food intake. There also was an inverse relationship between thiamine intake and reports of severe headaches.

  • Lipid Pathway Dysfunction in Parkinson’s Disease

    In this large-scale study, the authors used a comprehensive untargeted lipidomic approach to determine the extent to which lipid dysregulation occurs in patients with Parkinson’s disease generally and in mutation carriers of one of the most common Parkinson’s disease risk genes, LRRK2. Further pathway analysis reveals sphingolipid metabolism, insulin signaling, and mitochondrial function as major metabolic pathways dysregulated in Parkinson’s disease.

  • Quality Improvement Programs Can Shrink Surgery’s Environmental Footprint

    Even simple initiatives can help departments cut waste and save money.

  • Pediatric Exposures to Toxic Substances in the Home

    A high percentage of calls to poison centers each year are for exposures in children younger than the age of 6 years. Many of these calls are prompted by exposures to substances commonly found in the home and can lead to significant morbidity and mortality even when the result of a small, exploratory exposure. An index of suspicion and a knowledge of toxidromes is critical to make an accurate diagnosis in cases of pediatric toxic exposures. Consultation with a medical toxicologist or poison control center is recommended for all suspected toxic ingestions, both for management recommendations and for reporting purposes.

  • Housing Instability Associated with Longer Hospital Stays, Higher Costs

    New data reveal some insight on a key social determinant of health.

  • Tackling Obesity with Afterschool Programs

    This prospective study following 75 low-income middle school students found that adding nutrition education and physical activity requirements to afterschool programming may enhance gains in some health behaviors and weight management.

  • Patients with Chronic Pain and Opioid Misuse — What Treatment Works?

    A randomized, controlled trial involving 250 primary care patients diagnosed with comorbid chronic pain and opioid misuse found that a specially designed, mindfulness-based group therapy showed superiority to generic supportive group therapy in reducing opioid use and controlling symptoms of chronic pain.

  • Just How Good is ‘Good’ Cholesterol?

    Investigators challenge high-density lipoprotein levels as the standard for predicting cardiovascular disease risk.