This paper illustrates that, of the confirmed genetic forms of Parkinson’s disease, there are common cognitive and psychiatric features, thus adding to our knowledge of the clinical phenotype of these genetic forms.
A mindfulness yoga program was more effective than stretching and resistance training in addressing the symptoms of depression and anxiety in patients with mild to moderate Parkinson’s disease; both interventions showed equal efficacy in improving symptoms related to motor impairment.
A systematic review and meta-analysis incorporating more than 500,000 subjects revealed that moderate to vigorous physical activity is associated with a significant reduction in development of Parkinson’s disease; this relationship is most pronounced in men.
Mood, cognitive, and behavioral changes in tremor-predominant Parkinson’s disease patients, three and 12 months after receiving MRI-guided focused ultrasound thalamotomy, were correlated with quality of life more than the severity of tremor reduction.
Frequent consumption of dairy products is associated with a modest increased risk of Parkinson’s disease (PD) in women and men. In addition, intake of high-fat dairy is associated with decreased risk of PD.
A meta-analysis of 142 studies demonstrated that functional imaging studies in Parkinson’s disease using tracers for aromatic acid decarboxylase showed smaller defects compared to those using tracers targeting dopamine transport and VMAT2. Symptom severity correlated linearly with dopamine neuron loss as determined by these imaging studies.
This population-based study using Medicare data demonstrated that in the five years prior to diagnosis of Parkinson’s disease (PD), when compared with age-matched controls, those who were diagnosed with PD had a higher incidence of traumatic brain injury (TBI). The TBI was rated as mild and concussive and was most often related to falls.
This study comparing 20 individuals who received MRI-guided focused ultrasound thalamotomy with seven individuals who received sham treatment showed improvements in Parkinson’s disease tremor. Side effects were similar to prior studies of this technology for essential tremor, with ataxia and limb/orofacial paresthesias being most common.