In this observational cohort study of patients with singleton gestation and positive coronavirus test, patients with severe or critical disease were at risk for perinatal complications compared to those who were asymptomatic. Patients classified with mild or moderate disease were not shown to have an increased risk compared to asymptomatic positive patients.
The tool is particularly effective at illuminating which patients are at both ends of the severity spectrum, which can be helpful to emergency clinicians as they make their disposition decisions. Still, it is up to clinicians to consider the information provided, and then use their clinical judgment.
A large database observational study of patients with chronic aortic mild or moderate regurgitation (AR) largely due to bicuspid aortic valve or aortic root dilatation showed that it was largely an indolent disease, with only 20% progressing to moderately severe AR in five years.