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This award-winning blog supplements the articles in Hospital Infection Control & Prevention.

CDC’s ‘most wanted’ list of killer microbes

The Centers for Disease Control and Prevention has singled out 18 particularly bad bugs in a new report that includes an electron microscopy mug shot and a threat ranking of urgent, serious or concerning.

The threat rankings are a new approach, and help prioritize a problem that has become a public health call to action. The CDC threat rankings were based on seven factors associated with resistant infections: clinical impact, economic impact incidence, a 10-year projection of incidence, transmissibility, availability of effective antibiotics and barriers to prevention, the report states.1

The list of drug resistant organisms in the three categories are as follows:

Urgent Threats:

  • Clostridium difficile
  • Carbapenem resistant Enterobacteriaceae (CRE)
  • Drug-resistant Neisseria gonorrhoeae
Serious Threats
  • Multidrug-resistant Acinetobacter
  • Drug-resistant Campylobacter
  • Fluconazole-resistant Candida
  • Extended spectrum β-lactamase producing Enterobacteriaceae (ESBLs)
  • Vancomycin-resistant Enterococcus (VRE)
  • Multidrug-resistant Pseudomonas aeruginosa
  • Drug-resistant Non-typhoidal Salmonella
  • Drug-resistant Salmonella Typhi
  • Drug-resistant Shigella
  • Methicillin-resistant Staphylococcus aureus (MRSA)
  • Drug-resistant Streptococcus pneumoniae
  • Drug-resistant tuberculosis
Concerning Threats
  • Vancomycin-resistant Staphylococcus aureus (VRSA)
  • Erythromycin-resistant Group A Streptococcus
  • Clindamycin-resistant Group B Streptococcus