November 1, 2016
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Decompressive craniectomy for the treatment of refractory intracranial hypertension in patients with severe traumatic brain injury reduced mortality but increased rates of vegetative states, lower severe disability, and upper severe disability compared to continued medical management.
In a Phase II, randomized, multicenter prospective trial, intravenous glyburide failed to improve outcomes in patients with large hemispheric infarction, although there was a reduction in neuroimaging and biomarkers of cerebral edema.
Current guidelines recommend the use of therapeutic hypothermia in patients with in-hospital cardiac arrest, even though its efficacy has been demonstrated only in randomized trials after out-of-hospital cardiac arrest. This non-randomized, observational cohort study based on a large national registry found that the use of therapeutic hypothermia was associated with lower likelihood of survival and less favorable neurological outcome in patients successfully resuscitated after an in-hospital cardiac arrest.
In approximately 50,000 individuals with Parkinson’s disease and diabetes, identified from a National Health Insurance database in Taiwan, statin use was dose-dependently associated with lower risk of Parkinson’s disease. This strengthens the argument for a possible protective role of statins.