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In this paper, Packer et al report on the modes of death in patients in the Sudden Cardiac Death-Heart Failure Trial (SCD-HeFT).
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The preoperative use of angiotensin-converting enzyme inhibitors (ACEI) with coronary artery bypass graft (CABG) surgery is controversial. Thus, these investigators from the United Kingdom performed a retrospective, observational study of patients undergoing isolated CABG who did not have cardiogenic shock.
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Coronary revascularization without cardiopul-monary bypass has become quite successful, in part because of the belief that off-pump coronary bypass procedures are safer than on-pump surgery.
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Two recent studies have demonstrated the bene-ficial effects of nicotinic acid (niacin) on carotid artery atherosclerosis.
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Intensive lipid lowering with statin therapy (atorvastatin 80 mg) in patients presenting with acute coronary syndromes (ACS) resulted in improved outcomes compared to treatment with moderate lipid lowering (pravastatin 40 mg) in the PROVE-IT TIMI-22 study (Cannon et al. N Engl J Med.
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Anticoagulation during percutaneous coronary intervention (PCI), although necessary to prevent thrombus formation on the interventional equipment, can lead to significant morbidity from bleeding complications, particularly if the dosage is excessive.
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Results from a Phase 3 study of dabigatran, intensive lipid-lowering in CVD, H1N1 vaccine dosing and efficacy, and FDA Actions
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In this paper, Dhruva et al examine the types of studies that were involved in premarket approval (PMA) of cardiovascular devices by the FDA over a seven-year period.