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Medication poisonings in children; rosuvastatin vs atorvastatin for atherosclerosis; saw palmetto for prostate symptoms; using atypical antipsychotics for off-label indications in adults; and FDA actions.
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In an epidemiologic analysis of SEER data, middle-aged patients with early-stage disease who opted for active surveillance rather than retroperitoneal lymph node dissection experienced a greater rate of second malignancy. The investigators speculate that this may relate to increased radiation exposure (multiple CT scans) and a greater likelihood of subsequent chemotherapy use.
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In a randomized, double-blind, placebo-controlled trial, clonidine and venlafaxine both proved superior to placebo in reducing hot flashes in breast cancer patients. The study was insufficiently powered to prove superiority of one drug over the other. However, venlafaxine produced earlier reductions and it appeared clonidine had more sustained effect (i.e., at 12 weeks of treatment).
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In this issue: New recommendations for HPV vaccine; guidelines for treatment of essential tremor; updates on smoking cessation drugs; and FDA actions.
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The objective of this study was to estimate the use of vte prophylaxis in women undergoing major gynecologic surgery and to estimate the patient, physician, and hospital characteristics associated with their use.
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The author informs us that the winner of the 2010 Tour de France was Alberto Contador, riding a Specialized SL3 racing bike. The U.S. rider Chris Horner finished 12 minutes behind riding a Trek, Madone. The best rookie finisher, Daniel Loyd, rode a Cervelo S3, and finished more than 4 hours behind the leaders.
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In an otherwise normal preterm pregnancy, is oligohydramnios a reason to deliver? This question has popped up repeatedly, and an article in the September issue of the American Journal of Obstetrics and Gynecology addressed this conundrum.
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As U.S. waistlines continue to grow, so does the concern regarding obesity's effects on health and health care.