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In this study, the authors attempt to develop a risk stratification score to predict bleeding in patients treated with warfarin oral anticoagulation.
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In patients with severe valvular aortic stenosis (AS), ascending aortic dilatation is common, and is thought to be due to the alterations in flow caused by the stenotic valve.
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The Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) study showed that in patients with stable coronary artery disease (CAD) put on optimal medical therapy (OMT) that randomization to a percutaneous coronary intervention did not improve survival or prevent myocardial infarction.
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The authors conclude that even short-term treatment with most NSAIDs was associated with increased risk of death and recurrent MI in patients with prior MI. Neither short- nor long-term treatment with NSAIDs is advised in this population, and any NSAID use should be limited from a cardiovascular safety point of view.
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Two new drugs for treatment of hepatitis C; NSAIDs and myocardial infarction risk; AIM-HIGH clinical trial stopped; and FDA actions.
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In this paper, Haines and his coauthors propose a scoring system to predict risks associated with implantable cardioverterdefibrillator (ICD) implant procedures.
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RE-LY randomized 18,113 patients to one of its three arms. In the entire study group, dabigatran 110 mg twice per day compared with warfarin was associated with lower risks of major bleeding (2.87% vs 3.57 %), intracranial bleeding (0.23% vs 0.76%), and life-threatening bleeding (1.24% vs 1.85%).
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Several studies have shown lower rates of arterial access site complications when performing cardiac catheterization via the radial artery compared to the femoral artery, but these have largely been retrospective studies or registries.
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Thoracic aortic dissection is notoriously difficult to diagnose. Since the presenting symptoms are protean, it is not feasible to image everyone with symptoms that could be due to dissection.
