Clinical Publication
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Cumulative Number of Head Strikes Contributes to the Development of CTE
A recent study evaluated the connection between head impact and chronic traumatic encephalopathy (CTE) in male athletes and found that the total number and severity of head impacts throughout life better predicted CTE than the number of symptomatic concussions.
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Are You Sitting Down to Read This? You May Want to Stand Up
A large prospective cohort study demonstrated that prolonged sitting at work increases the risk for all-cause and cardiovascular disease mortality, but even short periods of physical activity throughout the day may help mitigate the negative effects.
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Identifying and Responding to Potential Cases of Human Trafficking in the Primary Care Setting
This paper aims to equip the primary care provider with the knowledge and skills to identify and respond effectively to potential cases of human trafficking in a primary care setting. When seeking care, individuals caught up in trafficking are most likely to present to an emergency room or urgent care, but about 40% go to private practices or clinics. An astute primary care provider has a unique opportunity to educate, intervene, or assist a patient at this point, should the individual be looking for this type of intervention.
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Effect of Atrial Fibrillation Catheter Ablation on Psychological Well-Being
A randomized trial of catheter ablation vs. medical therapy for atrial fibrillation (AF) patients has shown that anxiety and depression scores are significantly reduced by catheter ablation and are associated with decreases in AF burden and improved physical symptoms.
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Long-Term Antiplatelet Therapy After PCI
The five-year follow-up of patients randomized to clopidogrel vs. aspirin monotherapy beyond one year after percutaneous coronary intervention has shown that clopidogrel is noninferior, but not superior, to aspirin for preventing the combined endpoint of adverse cardiovascular or major bleeding events.
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PFO Closure Review Shows High Proportion of Off-Label Use
In this retrospective cohort study using administrative data from a U.S. payor source, only 58.6% of patients undergoing patent foramen ovale closure had the procedure done for the approved indication of stroke or systemic embolism. A significant proportion of patients were outside the recommended age range.
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Do Patients Feel Better After Tricuspid Valve Clipping?
A further analysis of the quality-of-life parameters in a trial of tricuspid transcatheter edge-to-edge repair (T-TEER) in patients with severe symptomatic tricuspid regurgitation vs. medical therapy alone has shown that T-TEER is associated with significant benefits in physical functioning and quality of life that are sustained for one year and were proportional to the magnitude of regurgitation reduction.
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Does Anyone with Severe Aortic Stenosis Not Benefit from TAVR?
A single-center, retrospective study of low-flow low-gradient aortic stenosis patients has shown that a gradient < 20 mmHg identifies a high-risk group because of significant comorbidities that may not benefit from transcutaneous aortic valve replacement.
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Imported Gestational Malaria
Pregnant women can develop malaria in non-endemic areas, even when they are far removed from malaria exposure both geographically and temporally.
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Zuranolone Therapy for Depression in the Postpartum Period
Zuranolone was well tolerated and resulted in substantial improvement of depressive symptoms in the postpartum period, suggesting that it may be a promising new oral therapy for postpartum depression.