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  • Why You Should Outsource Your Weight Loss Treatment

    Participation in Weight Watchers resulted in a greater weight loss over a year than did clinical intervention in a primary care office.
  • 15 to Life – Limited Exercise and Mortality Risk

    Data from this large observational trial with an average follow-up of over 8 years suggest that even 15 minutes a day of moderate-intensity exercise, such as taking a brisk walk, provides significant health benefits in terms of lowered mortality risks and life extension.
  • Just the Flax – Lignans and Postmenopausal Breast Cancer

    In a case-control study using a biomarker for lignan intake, women with breast cancer who had higher levels of the biomarker post-diagnosis had a reduced risk of mortality over a median follow-up period of 6 years compared to women with low levels of the biomarker.
  • Chinese Herbal Remedy for H1N1

    Thousands of Chinese used a compound called maxingshigan-yinqiaosan (MY) for treatment of flu symptoms during the 2009 H1N1 epidemic. MY is a concoction of 12 different herbs, including toasted Herba ephedra, as well as qinghao, gypsum fibrosum, and rhizoma.
  • Vitamin E and Prostate Cancer

    The SELECT Trial investigators report on nearly 10 years of follow-up of participants in a study of selenium and vitamin E and the risk of prostate cancer. A small but statistically significant increased risk of prostate cancer appears to be associated with taking vitamin E supplements. These results are in disagreement with others in the literature, and the authors present no plausible biological explanation for them. Nonetheless, the balance of evidence does not appear to support any recommendation that physicians advise their middle-aged and elderly patients to begin vitamin E supplementation for prostate cancer prevention.
  • Tea Totaling: Green Tea and Cholesterol

    A well-done meta-analysis showed that green tea, either as a beverage or as a supplement, could help lower total and LDL cholesterol levels in a statistically significant manner, but has no effect on HDL. The degree of clinical impact is debatable; what is not debatable is the poor quality of most studies on green tea and cholesterol.
  • Can Fish Oil Interfere with Chemotherapy?

    This basic science paper explores the role of the tumor microenvironment in the development of tumor resistance to chemotherapy. Two distinct fatty acid molecules, endogenously produced by cancer cells in response to platinum-based chemotherapy drugs, were found to confer significant tumor chemoresistance. Remarkably, these two fatty acids also were shown to be present in several commercial fish oil products, and, of potential import to clinicians, the oral administration of small amounts of these fish oils induced tumor resistance to cisplatin in a mouse tumor model.
  • Constipation, Cardiovascular Disease, and the Connection

    In postmenopausal women, constipation is associated with having major risk factors for cardiovascular disease and increased cardiovascular risk.
  • From Questions to Answers: How Research Is Designed

    This is the second in a three-part series about the design and conduct of clinical research.
  • Adult Sickle Cell Anemia

    Sickle cell disease celebrated its 100th anniversary last year, prompting consideration of what has transpired for those with the disease since its description by Dr. James Herrick in 1910.