Wendy Thanassi, MA, MD, and Anil Menon, MD
Dr. Thanassi is Associate Chief, Emergency Medicine; Director, Occupational Health, Palo Alto Veteran's Administration Hospital, and Dr. Menon is Section of Emergency Medicine, Stanford University Medical Center
Dr. Thanassi and Dr. Menon report no financial relationships relevant to this field of study.
The travel medical kit is a traveler's added insurance policy. if all goes well, no Band-Aids will be opened, no pills will be taken, and no one will arrive home with so much as a cold. But if illness occurs on a trip, however minor, attainment of both the business and pleasure goals of the journey are at risk. While abroad, health resources may be hard to find or even nonexistent, so a well-planned travel medical kit can be both the prevention and the cure for minor medical mishaps.
A kit should be tailored to each traveler, their age, and their destination. There are corporate, leisure, and sporting travelers who are going to urban, suburban, and backcountry locations. The tourist in Berlin and the trekker in Bhutan can expect needs as different as the geography they are visiting. Further consideration should be given to length of the trip, the group size, and the medical expertise of the intended traveler.1 For instance, chemoprophylaxis for a long duration trip can be more complicated than for a short vacation, just as a travel kit for an expedition will be more robust.2,3 This article discusses variations on the traveler's medical kit as they apply to an individual traveler.
The Basics — For All Travelers
The best route to a healthful trip is through prevention. Pre-travel immunizations and prophylactic medications are the foundation on which the medical kit is built. No medical kit can treat rabies, hepatitis, or yellow fever, but sound pre-travel care and immunizations can obviate these dangers completely.4 An airport survey of US travelers showed that most were unaware of infection risks and did not complete a vaccination regime prior to travel.5 Preparation should begin at least one month in advance, and is especially important for elderly, pediatric, and HIV-infected travelers.6-8
Before going abroad, travelers should also ask their health insurance companies what their coverage is while overseas. Many policies cover "reasonable" expenses, but very few pay for evacuation to the United States, which can exceed $50,000. Many online services (such as CSA Travel Protection and traditional insurers such as American Express) provide expanded coverage that is priced by duration, location, mode of transportation, and intended activities.9 If one utilizes the travel insurance for expensive coverage abroad, a second opinion can serve to better justify an insurance claim. The US Consulate can provide a list of doctors and hospitals which can also be obtained in advance.
A medical kit can be kept in a small nylon bag, stuff sack, or box, as the traveler desires. The most comprehensive container is compartmentalized, compact, and water proof. Several pre-made kits, such as Adventure Medical Kits are available at outdoor stores and range from $20 to $400. The simplest kits contain antiseptic, bandages, over the counter medications, and forceps. They are a fine start, but they fall short of addressing a traveler's specific needs.
The medical kit itself should contain relevant important documents that can serve as a bridge to professional medical care should an emergency occur. Check www.travel.state.gov for the most recent recommendations. All travelers should consider carrying:
- A copy of their passport, in case the original is lost or evacuation is necessary;
- A copy of their health insurance plan and a claim form;
- Their immunization record (with dates), ideally on the internationally recognized International Certificate of Vaccination;
- A compilation of their medical history. This history should include current conditions (eg, asthma), current medications (including the strength of contact lenses or glasses), past illnesses (eg. heart attack), past surgical procedures (eg. appendectomy), medication allergies and their effect (penicillin-rash), and blood-type, if known;
- A copy of their electrocardiogram (EKG), if one has been done, and is medically relevant; and
- Money. A small stash of cash stowed in the medical kit can help insure treatment in the event the traveler is separated from their wallet. Many countries' medical facilities require cash up-front, even in the event of life-threatening illness.
Prescription medications should always be in the carry-on luggage to avoid loss or delay en route. Not only should there be enough medication for the entire trip, but additional doses should be included, and a complete duplicate supply should be considered. Contact lenses or glasses should also be carried on-board. Medic-Alert bracelets or necklaces should be worn at all times and not carried in handbags. Nonessential items, especially lotions or creams, should remain in the medical kit in the checked-in luggage.
Diarrheal disease, respiratory infections, and dermatologic conditions, as broad categories, are the most frequently encountered travel-related illnesses contracted in developing countries.10 Non-prescription medications are effective at alleviating many of these complaints and are among the most frequently used items from a travel kit.11
Nonprescription medications potentially useful for many nonpregnant travelers include:
- Acetaminophen for fever, headaches, or minor aches and pains;
- Antibiotic ointment (Bacitracin, Polysporin) for cuts, scrapes, bites or burns;
- Antifungal creams for athlete's foot, tinea inguinalis, ringworm;
- Antihistamines such as diphenhydramine (Benadryl) for assistance sleeping, allergic reactions and seasonal allergies, and dimenhydrinate (Dramamine) for motion sickness;
- Calcium carbonate (Tums) for acid reflux;
- Ibuprofen (Advil, Motrin) or aspirin for fever; headaches, minor aches and pains, sore muscles, and inflammatory swelling;
- Latex condoms for protection against sexually transmitted diseases, if indicated for such travelers;
- Loperamide (Imodium) for diarrhea; and
- Pseudoephedrine HCL (Sudafed) for nasal and sinus congestion.
Corporate and Leisure Travel
International business trips are fraught with stressors. Often the journey will demand a large investment of time and resources, and can also carry high expectations from colleagues. In addition, the business traveler is subjected to the stress of airports, long flights, immigration lines, foreign currencies, foreign languages, and time changes.
While the air is recirculated on commercial jets, documentation of passengers contracting serious illnesses is rare.12,13 The famous report in the New England Journal of Medicine of "probable" transmission of multi-drug resistant tuberculosis only recorded a positive skin-test among fellow passengers, and neither illness in exposed passengers nor strain-typing to match the index case were identified.14 To date, no definitive cases of SARS (severe acute respiratory syndrome) have been transmitted onboard, though the data for such long flights is sparse. Without question, it has become prudent for travelers en route to endemic areas to have protective face-masks, available over the counter in all major pharmacies. The N-95 mask is recommended. It resembles a surgical mask and includes a filter that keeps out 95 percent of particles that are 0.3 microns across or larger.
Colds and other upper respiratory infections have been thought to be readily and frequently contracted onboard airplanes. However, a 2002 JAMA study of 1100 passengers found no evidence that common upper respiratory symptoms increased after travel, though the study was only conducted on the 2-hour San Francisco to Denver route.15 It is best for the traveler be aware that the risk of infectious transmission is likely to exist and keep headache and sinus relievers with them. In the event of a bacterial respiratory infection, a macrolide antibiotic will cover the healthy traveler, and a respiratory fluoroquinolone will treat travelers with respiratory comorbidities.
Jet-lag is frequently problematic on business trips when inflexible schedules do not permit adaptation. It is usually apparent when more than 5 time zones are crossed and more often with eastward travel.16 Traveling toward the east makes it difficult to be alert for morning meetings, whereas westward travel makes late business and dinner meetings initially taxing. Coping strategies include the use of hypnotics during overnight flights and approximately 2-5 mg of melatonin (adult dose) to simulate night time endocrine function. Though there is some controversy, current literature supports the use of melatonin at bedtime to reduce jetlag, and related side effects are few.17,18 Another effective strategy, used by NASA astronauts, involves changing bedtime prior to travel in anticipation of the target bedtime. This process may be overly cumbersome for most travelers. Bright lights will suppress melatonin secretion for increased daytime wakefulness.
Jet-lag, specifically after crossing 7 time zones, was shown to significantly increase the likelihood of a schizophrenic break in patients with a history of such pathology. Psychotic breaks were seen with increased frequency, even among persons who had been symptom-free for over a year.19 Patients with this history should consult their psychiatrists, and may be advised to bring antipsychotic medications along.
Marine transportation and cruise ship passengers are at risk for the diseases endemic to the ports at which they dock. Passengers and crew who disembark may bring aboard infections from land, most notoriously travelers' diarrhea. Motion sickness caries the potential to ruin a scenic trip and continue for hours post disembarkation. Dimenhydrinate (Dramamine 50-100 milligrams each 6 hours) and hyoscine (Scopolamine, which is a tropane alkaloid drug obtained from plants of the nightshade family), transdermal patches applied 4 hours prior to travel, are effective at reducing symptoms. Scopolamine is contraindicated for people with glaucoma or urinary retention. Ondansetron oral dissolving 4 milligram tablets can still be absorbed during vomiting and will help with nausea onboard or at any time during travel. These are all adult doses.
Sexual relationships are a common part of travel for some, and the risk of sexually transmitted diseases, including hepatitis B and C, HIV, gonorrhea, and chlamydia infections can be prevented through proper and consistent condom use. Condoms made of natural materials do not prevent transmission of HIV.
Allergic reactions to foods and hymenoptera stings are more likely to occur overseas than at home since the new ingredients introduced into the diet and types of bees and wasps vary regionally. All travelers with a history of severe allergic reaction should have IM epinephrine (EpiPen), an H1-blocker (diphenhydramine 50 mg q8 hours for 2 days), an H2-blocker (famotidine 20 mg bid), and prednisone 60 mg with them, as detailed below in the Envenomations section of Backcountry Travel. Again, these are adult doses.
Hay-fever, or seasonal environmental allergies, are unpredictable when overseas. Cough, congestion, rhinorrhea, and eye irritation can be inconvenient and uncomfortable. A thorough medical kit should include a nasal steroid such as fluticasone propionate (Flonase), a non-sedating antihistamine such as cetirizine HC1 (Zyrtec) 10 mg daily and an antihistamine eye drop such as olopatadine HC1 (Patanol).
Women are more prone to more urinary tract infections (UTIs) and yeast infections while traveling than at home due to dehydration and possible changes in hygiene. Fluconazole 150 mg as a single dose should be brought for vaginal candidiasis. An antibiotic such as trimethoprim/sulfamethoxazole (a double-strength tablet, 1 bid for 3 days) or a fluoroquinolone (ciprofloxacin 500 mg bid for 5 days) is wise to include. Phenazopyridine (Pyridium) (200 mg tid for 2 days) is very helpful for UTI pain relief. Note that it turns urine, tears, and contact lenses orange, and patients should know this.
Another necessary item for leisure and for high altitude travel is sunscreen. It is important to cover both UVA, which is involved with photoaging and cancer, and the UVB spectrum, which is directly connected with sunburn as well as cancer. Avobenzone and oxybenzone or zinc provide broad coverage. Though a tee shirt does not sufficiently block UV rays, commercially-available material with SPF ratings do extend protection.
Backcountry and High Altitude Travel
While little mortality data is available around the world, Nepal recorded that the most frequent cause of death in trekkers in the 1980s was trauma, followed by "illness" and acute mountain sickness. As older persons seek adventure in the wilderness, mortality from medical illnesses is likely to increase. In mountainous countries other than Nepal, whose famous Himalayan Rescue Service averts many potential tragedies, mortality from trauma is likely to be higher. Adventure trekkers must have appropriate trauma and high altitude treatments in their medical kits. Supplies for preexisting medical illnesses are discussed above.
For traumatic injuries and wounds, medical kits should include antiseptics/cleansers, wound adhesives, bandages, splints, antibiotics, and pain control. A list of suggested items follows:
- Basic non-latex (nitrile) hospital gloves for cleaning and bandaging wounds. These are very versatile and useful and help prevent the spread of infections;
- Antibacterial wipes or towelettes;
- A 20 mL syringe for irrigating wounds, since studies show that the pressure of the applied solution is more important than which clean irrigation solution is used; an irrigation shield reduces the splash and narrows the diameter of the stream to increase the pressure and decreases bloody fluid splashing on the caregiver;
- Povidone iodine solution (Betadine) for disinfecting the irrigation water and cleaning around wound margins;
- Lidocaine impregnated first-aid cleansing pads; 4% topical lidocaine jelly such as LMX can aid in pain relief and manipulation;
- Oil of cloves (Eugenol) dental anesthetic for dental injury;
- Dermabond tissue adhesive or other 8-octyl cyano acrylate;
- Wound-closure strips (Steri-Strips) and tincture of benzoin solution for their adhesion;
- Skin staples (3M Precise Disposable Skin Stapler), which is used like a staple-gun once the wound has been cleaned and the wound edges are approximated;
- Antibiotic ointment (bacitracin/neomycin) for minor wounds, abrasions, and those closed with Steri-Strips (ointment cannot be placed on top of Dermabond as it will dissolve it);
- A variety of bandaging materials including non-adhesive sterile dressings like Telfa pads, and gauze roller bandages, 2nd Skin, moleskin and the ever-important, highly versatile duct tape;
- A Sam Splint, which is a lightweight, malleable splint which can be molded into anything from a cervical collar to an ankle splint; and
- Ibuprofen, 800 mg each 8 hours taken with food as needed for pain (adult dose).
When the potential for serious trauma such as a femoral fracture exists, kits should include:
- Intravenous catheters, intravenous tubing, and a few liters of normal saline; and
- Strong pain medication. Note that codeine-containing pills ideally should not be carried across a border and can often be purchased over-the-counter in local pharmacies to bring on backcountry trips. But narcotic pain relievers such as morphine for IM use and oxycodone/acetaminophen (Percocet 1-2 q 4-6 hours for adults) for pain control, accompanied by a letter from a physician regarding the amount included and its intended use, should be included when access to medicine abroad is expected to be difficult.
Commercial suture and syringe kits are available for sale (Travel Medicine, Inc 1-800-TRAVMED, www.travmed.com) and can be used by the traveler or given to the local health-care provider in areas where syringes may be being reused.
Regionally-based illnesses should be investigated before the trip on the web at www.cdc.gov and addressed in one's pre-travel medical appointment. Trekkers can be exposed to malaria, typhoid fever, meningitis, yellow fever, Japanese encephalitis, cholera, and parasites among others infections. Appropriate immunization and chemoprophylaxis for these diseases is certainly the best medicine.
1) Travelers' Diarrhea (TD)
Diarrheal pathogens are ubiquitous. Avoidance of unpurified water and of foods (lettuce is notorious) that have come into contact with dirty water or hands is of paramount importance. Despite these attempts, diarrhea strikes 20-50% of travelers to developing countries. While rarely life-threatening, 10% of cases last more than a week. Bacteria comprise 50-75% of isolates, while less than 20% of isolates are viruses and less than 5% are protozoan.20
While prophylactic antibiotics for travelers' diarrhea are not recommended, data on rifixamin showed that when given in a dose of 200 mg one to three times daily for 2 weeks to newly arrived US students to Mexico, it provided protection rates of 72%-77% against travelers' diarrhea and travelers' diarrhea requiring antibacterial therapy, respectively (P < 0.001 for both). Rifixamin taken three times a day for three days to date has demonstrated little antimicrobial resistance.21
Currently not available in the United States, but available over-the-counter in Canada, Dukoral™ is a vaccine developed to prevent cholera but also has efficacy against travelers diarrhea. It is an oral formulation of several inactivated cholera variants and has relatively few side effects as of yet. It is the non-toxic B subunit of the cholera toxin that is also included in the vaccine which conveys some immunity against traveler's diarrhea. In a randomized, double-blind study done in Bangladesh in 89,596 adults and children aged 2 years and older, Dukoral conferred 67% (95% CI, P = .02) protection against episodes of diarrhea caused by enterotoxigenic E. coli synthesizing heat-labile toxin (LT-ETEC), 86% protection against clinically severe episodes of LT-ETEC, and 85% protection against cholera.22 Another efficacy study was conducted in 1992 in 502 US students going to Mexico. In this study, the vaccine was given after arrival in Mexico.23 The study found 50% protective efficacy against ETEC. The oral Dukoral™ vaccine should be taken 14, and again 7 days before travel.
Boiling water for one minute remains the most effective way to kill bacteria (3 minutes to kill viruses), but medical kits should also include water treatment tablets or filters. Iodine tablets and tincture are unreliable for eliminating Cryptosporidium unless the treated water sits overnight. Twice the recommended amount should be used when water is visibly dirty. Chlorine is a chemical disinfectant that has variable germicidal activity. Microstrainer portable filters (0.1-0.3 m) do not remove viruses, though filters impregnated with iodine kill some viruses but may miss Cryptosporidium and Giardia in cold water. There are no reliable scientific reports evaluating specific brands, but PUR™, MSF™ and Sweet Water™ are the most popular brands.
For treatment, fluid rehydration with an electrolyte solution prevents dehydration and is usually adequate treatment by itself. The World Health Organization's Oral Rehydration Solution packets are readily available, but for the average healthy adult, rehydrating with any fluid that contains both salt and sugar (electrolytes) is sufficient. Rehydrating with water alone can further deplete essential elements. An easy to make and equivalent formulation involves mixing one liter of water with 1 teaspoon of salt, 8 teaspoons of sugar. A banana (for potassium) can be added.
Lactobacillus tablets and yogurt are widely used "home" remedies, but no clinical evidence supports their use. Bismuth subsalicylate (Pepto-Bismol ) in high doses (1 ounce or 525 mg every 30 minutes for 8 doses) was effective in several placebo-controlled trials.24 High doses of this salicylate product are unsafe in persons with renal disease or aspirin allergy.
Loperamide (Imodium) and codeine-containing products act as constipating agents and can provide rapid relief in simple TD. Such antimobility agents can worsen disease when the offending bacteria are toxin-producing because they lengthen the amount of time the toxin stays in the intestinal tract. Antimobility agents are discouraged, therefore, when there is a high fever or bloody diarrhea. Promethazine (Phenergan) 25 mg suppositories or ondansetron oral dissolving tablets each 4-6 hours are effective antiemetics with few side-effects (adult dose).
Antimicrobials can be used after the onset of diarrheal disease, especially when accompanied by fever, vomiting, or bloody stools. Antibiotics will shorten the illness by 1 to 1.5 days. Fluoroquinolones used to be the antibiotics of choice with ciprofloxacin, 500 mg bid for 3 days most often used. However, in some areas of the world, specifically southeast Asia, ciprofloxacin resistance by Campylobacter jejuni is approaching 90%.25,26 Azithromycin administered as 1 gm PO or 500 mg daily for 3 days is currently an effective regimen in adults.
Far more common abroad than in the United States, parasites such as Cryptosporidium can cause diarrhea, or Trichuris trichiura (whipworm) can cause abdominal pain and a breadth of gastrointestinal complaints, and Giardia lamblia can cause profuse malabsorptive diarrhea. These diseases can be significantly debilitating and quickly divert a trip. Nitazoxanide (Alinia) in doses of 500 mg twice daily for 3 days in adults can effectively treat these parasites. It is important to differentiate diarrhea secondary to parasite infection from the far more common TD.
Approximately 7 million Americans travel to malaria-endemic areas annually. Infection rates and antimalarial susceptibilities vary widely by region. Malaria prophylaxis is critically important. Consultation with wwwn.cdc.gov or a similar website will elucidate regional recommendations based on resistance patterns. These might include Mefloquine 250 mg per week started 1-2 weeks prior to travel and continued one month post travel. Another option is daily doxycycline 100 mg started 1-2 days prior to travel and also continued for a month post travel. If the neuropsychiatric side effects of mefloquine or the photosensitive or gastrointestinal effects of doxycycline are intolerable then atovaquone-proguanil (Malarone) 250/100 mg daily will also work if taken 1-2 days prior to travel and continued 7 days post travel. Doses for both are for adults. Staying indoors during the prime biting hours of dusk-to-dawn will reduce the probability of infection, as will insect repellent that contains N,N-diethyl-meta-toluamide (DEET), and permethin-treated bednets.
In the event of prophylactic failure and a more than 24 hours' distance to a medical facility, a self-treatment regimen for malaria should be in all at-risk travelers' kits. Self-care is initiated if a high fever develops with or without persistent headache, muscle aches and weakness, vomiting, or diarrhea. Malaria can be fatal if treatment is delayed. Prompt medical evaluation remains imperative, and attempts should be made to reach appropriate facilities even after treatment is initiated.
For patients who contract malaria and who did not take prophylaxis, or who took prophylaxis other than atovaquone-proguanil, the only drug recommended for self-treatment is atovaquone-proguanil taken as 4 tablets per day for 3 days (1000/400 per day for adults). For patients who were taking atovaquone-proguanil prophylaxis but developed breakthrough malaria, consultation with medical professionals is necessary, and further use of atovaquone-proguanil will be ineffective and could prove dangerous. Potential side effects of Malarone include abdominal pain, nausea, vomiting, and headaches.27
Malarone™ is active against the erythrocytic and exoerythrocytic stages of P. falciparum malaria. In 10 clinical trials in adults and children, Malarone cured 96.7% of 521 cases of P. falciparum malaria. However, relapses from the exoerythrocytic stages of P. vivax and P. ovale can occur and may require further treatment with primaquine.
Importantly, several of the prophylactic medications are not recommended for use in presumptive self-treatment. Mefloquine can have serious neuropsychiatric side effects when taken in high doses. Halofantrine (Halfan), which is readily available overseas, may cause cardiac abnormalities and is particularly discouraged in patients taking mefloquine prophylaxis.
A CDC-sponsored malaria hotline is available. See resource #4 for information regarding obesity.
Other envenomations, such as bee stings, are even more likely overseas. Rarely, African "killer" bees can form dozens of hives in close approximation and have no seasonal barrier to their swarming activity. EpiPen emergency injections of epinephrine might be included in the kit, and appropriate teaching of its use imparted on the traveler to a true high-risk area. An H1 and an H2-blocking antihistamine (Diphenhydramine 50 mg and Famotidine 20 mg adult dose) should be immediately given by mouth if the person having the allergic reaction can swallow. Prednisone (60 mg) should also be given.
Snake and poisonous spider envenomations are generally best managed with thorough wound-care management and medical follow-up.
Acute Mountain Sickness (AMS) and High-Altitude Travel
At 9,000 feet of altitude, approximately 20% of travelers will experience acute mountain sickness. It reaches 50% at extremely high altitudes that are > 18,000 ft. Acute mountain illnesses can be as mild as headaches, anorexia, and nausea or as severe as pulmonary (HAPE) or cerebral edema (HACE). There is some evidence that acetazolamide (Diamox) 125-250 mg twice a day, starting the first day of ascent and continuing for 48 hours after reaching maximal altitude, can be used prophylactically. The mechanism is interesting: decreased ventilation and relative hypoxemia contribute to the development of AMS; acetazolamide promotes renal excretion of bicarbonate, causing metabolic acidosis, compensatory hyperventilation and improved oxygenation. Travelers generally reported a tingling sensation in their extremities with use of acetazolamide.
Dexamethasone has been used for prevention but is now mainly recommended for treatment of AMS.28 As a treatment, dexamethasone is given as an 8 mg initial dose, followed by 4 mg every 6 hours in adults.
High-altitude pulmonary edema is a noncardiogenic edema that is caused by hydrostatic forces rather than by either inflammation or primary "pump" failure.29 Nifedipine SR 30 mg orally each 12-24 hours, or 10 mg sublingual each 4-6 hours, reduces pulmonary vascular resistance and pulmonary artery pressure and improves oxygenation in adults.
There are also lightweight, portable hyperbaric bags (Gamow) that are large enough to hold one person. The bag is inflated by a manual air pump, and its pressure simulates descent. Inflation to only 2 psi corresponds to a drop in altitude of approximately 5,000 feet, potentially life-saving in the event of HAPE or HACE. Disadvantages include a weight of approximately 5 kg, potential for claustrophobia in the patient, and the need for continual pumping to maintain fresh air circulation in the bag. These can even be rented for short and long expeditions.
For women taking estrogen-containing birth-control pills, the already increased risk of thromboembolism may be further increased. Physicians may wish to discuss the use of progesterone-only compounds or other methods of birth control while patients are at altitude.
Another necessary item for high altitude travel and any travel medicine kit is sunscreen. It is important to cover both UVA, which is involved with photoaging and cancer, and UVB spectrum, which is more directly connected with sunburn, as well as cancer.
- Adventure Medical Kits 1-800-324-3517, www.adventuremedicalkits.com. Pre-made basic medical kits.
- Alertness Solutions, Inc. www.alertness-solutions.com. Products and information about jet-lag avoidance.
- Centers for Disease Control and Prevention. Health Information for the International Traveler. Atlanta: U.S. Department of Health and Human Services, Public Health Service, 2008. Available at: 877-252-1200 and http://wwwn.cdc.gov.
- CDC Malaria hotline, Monday-Friday 8am-4:30pm eastern; 770-488-7788. If emergency consultation is required after hours, call 770-488-7100 and request to speak with a CDC Malaria Branch clinician. www.cdc.gov
- Chinook Medical Gear Inc. Travel supplies including expedition gear and kits, www.chinookmed.com
- The Travel Doctor. Outstanding resource for malaria prophylaxis: http://www.traveldoctor.co.uk/tables.htm
- Travel Medicine, Inc. for commerical suture and syringe kits. 1-800-TRAVMED (872-8633); http://www.travmed.com/scripts/catalog.epl.
- Travelers' Diarrhea, National Institutes of Health Consensus Development Conference Statement. Volume 5, Number 8, 2000.
- Weiss EA. Travel Health and Medical Kits in Travel Medicine, J.S. Keystone, Editor. 2004, Mosby: Edinburgh. p. Ch 8.
- Chen LH, et al. Prevention of malaria in long-term travelers. JAMA. 2006;296:2234-2244.
- Townes DA, et al. Event medicine: Injury and illness during an expedition-length adventure race. J Emerg Med. 2004;27:161-165.
- Thanassi WT, Weiss EL. Immunizations and travel. Emerg Med Clin North Am. 1997;15:43-70.
- Connor BA., et al. Hepatitis B risks and immunization coverage among American travelers. J Travel Med. 2006;13:273-280.
- Bhadelia N, et al. The HIV-positive traveler. Am J Med. 2007;120:574-580.
- Maloney SA, Weinberg M. Prevention of infectious diseases among international pediatric travelers: Considerations for clinicians. Semin Pediatr Infect Dis. 2004;15:137-149.
- Reed CM. Travel recommendations for older adults. Clin Geriatr Med. 2007;23:687-713, ix.
- CSATravel, Online Quote, www.csatravelprotection.com. 2007.
- Rack J, et al. Risk and spectrum of diseases in travelers to popular tourist destinations. J Travel Med. 2005;12:248-253.
- Goodyer L, Gibbs J. Medical supplies for travelers to developing countries. J Travel Med. 2004;11:208-211.
- Leder K, Newman D. Respiratory infections during air travel. Intern Med J. 2005;35:50-55.
- Mangili A, Gendreau MA. Transmission of infectious diseases during commercial air travel. Lancet. 2005;365:989-996.
- Kenyon TA, et al. Transmission of multidrug-resistant Mycobacterium tuberculosis during a long airplane flight. N Engl J Med. 1996;334:933-938.
- Zitter JN, et al. Aircraft cabin air recirculation and symptoms of the common cold. JAMA. 2002;288:483-486.
- BMA, The Impact of Flying on Passenger Health: A Guide for Healthcare Professionals. 2004, British Medical Association. p. 1-44.
- Spitzer RL, et al. Jet lag: Clinical features, validation of a new syndrome-specific scale, and lack of response to melatonin in a randomized, double-blind trial. Am J Psychiatry. 1999;156:1392-1396.
- Herxheimer A, Petrie KJ. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev. 2002:CD001520.
- Katz G, et al. Time zone change and major psychiatric morbidity: The results of a 6-year study in Jerusalem. Compr Psychiatry. 2002;43:37-40.
- Ansdell VE, Ericsson CD. Prevention and empiric treatment of traveler's diarrhea. Med Clin North Am. 1999;83:945-973, vi.
- DuPont HL, et al. A randomized, double-blind, placebo-controlled trial of rifixamin to prevent travelers' diarrhea. Ann Intern Med. 2005:805-812.
- Clemens JD, et al. Cross-protection by B subunit-whole cell cholera vaccine against diarrhea associated with heat-labile toxin-producing enterotoxigenic Escherichia coli: Results of a large-scale field trial. J Infect Dis. 1988;158:372-377.
- Scerpella EG, et al. Safety, immunogenicity, and protective efficacy of the whole-cell/recombinant B subunit (WC/rBS) oral cholera vaccine against travelers' diarrhea. J Travel Med. 1995;2:22-27.
- DuPont HL. Travelers' diarrhea: Antimicrobial therapy and chemoprevention. Nat Clin Pract Gastroenterol Hepatol. 2005;2:191-198.
- Marcos LA, Dupont HL. Advances in defining etiology and new therapeutic approaches in acute diarrhea. J Infect. 2007;55:385-393.
- Vila J, et al. Quinolone resistance in enterotoxigenic Escherichia coli causing diarrhea in travelers to India in comparison with other geographical areas. Antimicrob Agents Chemother. 2000;44:1731-1733.
- Griffith K, et al. Treatment of malaria in the United States: A systematic review. JAMA. 2007;297:2264-2277.
- Hackett PH, Roach RC. High-altitude illness. N Engl J Med. 2001;345:107-114.
- Swenson ER, et al. Pathogenesis of high-altitude pulmonary edema: Inflammation is not an etiologic factor. JAMA. 2002;287:2228-2235.