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In 1854, london was rocked by a cholera epidemic that killed approximately 10,000 people. Using what are now considered classical epidemiological methods, Dr. John Snow traced the source of at least 500 of the infections to a single water pump at Broad Street, validating his theory that cholera was a water-borne disease 29 years before the etiologic agent was discovered by Robert Koch; removing the pump handle stopped the outbreak in that area.

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